Increased PA-Inhibitor Levels in the Postoperative Period – No Cause-Effect Relation with Increased Cortisol
Increased PA-Inhibitor Levels in the Postoperative Period – No Cause-Effect Relation with Increased Cortisol
复制标题
术后 PA 抑制剂水平升高——与皮质醇升高没有因果关系
作者：
M. Aillaud;I. Juhan;M. Alessi;M. Marecal;M. Vinson;C. Arnaud;Philippe Vague;D. Collen
摘要 据报道，术后患者的 PA 抑制剂水平升高，另一方面糖皮质激素会增加细胞培养物中的 PA 抑制剂水平。由于手术与血浆皮质醇水平升高相关，因此寻找术后血浆皮质醇升高与 PA 抑制剂水平之间的关系。采集 8 名接受广泛腹部手术的患者的血样，分别在术前和术后 2 小时、4 小时、24 小时以及每天采集，持续 7 天。手术后 2 小时血浆皮质醇和 PA 抑制剂增加，此时存在显着相关性 (p <0.05)。最大增加出现在 24 小时，第 6 天数值降至正常。t-PA 相关抗原 (t-PA R:Ag) 增加，优球蛋白纤溶活性 (EFA) 降低。 7 名对照者静脉注射 0.25 mg ACTH，并在 1/2、1、2、4、6 小时后收集血液。尽管 ACTH 后血浆皮质醇水平的增加与手术后观察到的相当，但增加与 PA 抑制剂水平、t-PA R：Ag 或 EFA 的显着变化无关。血浆皮质醇升高与 PA 抑制剂水平之间的因果关系无法显示。因此术后 PA 抑制剂增加的机制仍不清楚。
Summary It has been reported that the level of PA-inhibitor increases in postoperative patients and on the other hand that glucocorticoids increase the PA-inhibitor level in cell culture. Because surgery is associated with increased plasma cortisol level, a relation between the postoperative increase in plasma cortisol and PA-inhibitor levels was looked for. Blood samples were collected from 8 patients undergoing extensive abdominal surgery, before operation and postoperatively at 2 hr, 4 hr, 24 hr and daily for 7 days. Plasma cortisol and PA-inhibitor were increased 2 hr after surgery, when there was a significant correlation (p <0.05). The maximum increase was at 24 hr and the values fell to normal on day 6. An increase in t-PA related antigen (t-PA R:Ag) and a decrease in euglobulin fibrinolytic activity (EFA) also occurred. In 7 controls 0.25 mg ACTH was given intravenously and blood was collected after ½, 1, 2, 4, 6 hr. Although the increase in plasma cortisol level following ACTH was comparable to that observed after surgery the increase was not associated with significant change in PA-inhibitor level, t-PA R: Ag or EFA. A cause-effect relationship between the increased plasma cortisol and PA-inhibitor level could not be shown. The mechanism of the postoperative increase in PA-inhibitor thus remains unknown.
地塞米松诱导的肝癌细胞纤溶活性抑制剂。
DOI：
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发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Coleman,PL;Barouski,PA;Gelehrter,TD
通讯作者：
Gelehrter,TD