Alterations in Resting-State Functional Connectivity Link Mindfulness Meditation With Reduced Interleukin-6: A Randomized Controlled Trial
Alterations in Resting-State Functional Connectivity Link Mindfulness Meditation With Reduced Interleukin-6: A Randomized Controlled Trial
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DOI：
10.1016/j.biopsych.2016.01.008
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发表时间：
2016-07-01
影响因子：
10.6
通讯作者：
Ferris, Jennifer L.
中科院分区：
文献类型：
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作者：
Creswell, J. David;Taren, Adrienne A.;Ferris, Jennifer L.
背景技术背景：正念冥想训练干预已被证明可以改善健康指标，但其潜在的神经生物学机制尚不清楚。基于初步的横断面研究，正念冥想可能会增加默认模式网络（DMN）与自上而下执行控制重要区域的静息状态功能连接（rsFC）。（背外侧前额叶皮层[dlPFC]），在这里，我们测试了正念冥想训练是否会增加DMN-dlPFC rsFC，以及这些rsFC的改变是否可以前瞻性地解释白细胞介素（IL）的改善。方法：压力求职失业社区成年人（n = 35）被随机分配到一个为期3天的密集住宅正念冥想或放松训练计划。参与者在干预计划前后完成了5分钟的静息状态扫描。参与者还提供了血液样本在干预前和4个月的后续行动，这是测定循环IL-6，全身inflammation.RESULTS生物标志物：我们测试了DMN rsFC的变化使用后扣带皮层种子为基础的分析，发现正念冥想训练，而不是放松训练，增加后扣带皮层rsFC与左dlPFC（p <0.05，校正）。这些训练前到训练后的后扣带皮层-dlPFC rsFC的变化在统计学上介导了4个月随访时IL-6的正念冥想训练改善。具体而言，这些改变rsFC统计解释了30%的整体正念冥想训练的影响IL-6在follow-up.CONCLUSIONS：这些研究结果提供了第一个证据，正念冥想训练功能耦合DMN与一个区域已知是重要的自上而下的执行控制在休息（左dlPFC），这反过来，是与炎症性疾病风险的标志物的改善。
BACKGROUND: Mindfulness meditation training interventions have been shown to improve markers of health, but the underlying neurobiological mechanisms are not known. Building on initial cross-sectional research showing that mindfulness meditation may increase default mode network (DMN) resting-state functional connectivity (rsFC) with regions important in top-down executive control (dorsolateral prefrontal cortex [dlPFC]), here we test whether mindfulness meditation training increases DMN-dlPFC rsFC and whether these rsFC alterations prospectively explain improvements in interleukin (IL)-6 in a randomized controlled trial.METHODS: Stressed job-seeking unemployed community adults (n = 35) were randomized to either a 3-day intensive residential mindfulness meditation or relaxation training program. Participants completed a 5-minute resting-state scan before and after the intervention program. Participants also provided blood samples at preintervention and at 4-month follow-up, which were assayed for circulating IL-6, a biomarker of systemic inflammation.RESULTS: We tested for alterations in DMN rsFC using a posterior cingulate cortex seed-based analysis and found that mindfulness meditation training, and not relaxation training, increased posterior cingulate cortex rsFC with left dlPFC (p < .05, corrected). These pretraining to posttraining alterations in posterior cingulate cortex-dlPFC rsFC statistically mediated mindfulness meditation training improvements in IL-6 at 4-month follow-up. Specifically, these alterations in rsFC statistically explained 30% of the overall mindfulness meditation training effects on IL-6 at follow-up.CONCLUSIONS: These findings provide the first evidence that mindfulness meditation training functionally couples the DMN with a region known to be important in top-down executive control at rest (left dlPFC), which, in turn, is associated with improvements in a marker of inflammatory disease risk.