Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways
Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways
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DOI：
10.1016/j.neulet.2012.02.054
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发表时间：
2012-04-11
影响因子：
2.5
通讯作者：
Wei, Jia
中科院分区：
文献类型：
--
作者：
Li, Xian-Hui;Li, Chun-Yan;Wei, Jia
大量研究表明，学习和记忆能力在正常衰老过程中，认知能力趋于下降，Nrf2的表达似乎也随着年龄的增长而下降。因此，Nrf2通路已被确定为治疗神经退行性疾病的一个有前途的靶点。有机硫磺化合物大蒜素可以激活Nrf2，因为它有一个亲电中心，可以作为亲核分子的攻击部位，例如Keap1上存在的特定蛋白质巯基。然而，大蒜素对衰老引起的认知障碍的影响还没有被研究。在这项研究中，我们评估了大蒜素对认知受损老年小鼠海马区内源性抗氧化防御的影响。我们的结果表明，大蒜素的治疗显著改善了衰老引起的认知功能障碍，这是通过增强Nrf2抗氧化信号通路来实现的。因此，大蒜素可能被推荐作为预防和治疗老年性认知障碍和阿尔茨海默病的候选药物。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Numerous studies have demonstrated that learning and memory abilities in the course of normal aging cognitive abilities tend to decline and Nrf2 expression appears to decline with aging. So, Nrf2 pathway has been identified as a promising therapeutic target for neurodegenerative diseases. The organosulfur compounds, allicin can activate Nrf2, because it has an electrophilic center, which can serve as an attack site for nucleophiles, such as specific protein sulfhydryl groups present on Keap1. However, the influence of allicin on aging-induced cognitive deficits has not been examined. In this study, we assess the effects of allicin on endogenous antioxidant defenses in hippocampus of cognitively impaired aged mouse. Our results indicate that treatment of allicin significantly ameliorated ageing-induced cognitive dysfunction through enhancing of Nrf2 antioxidant signaling pathways. Therefore, allicin could be recommended as a possible candidate for the prevention and therapy of cognitive deficits in aging and Alzheimer's disease. (C) 2012 Elsevier Ireland Ltd. All rights reserved.