Phase change microvalve for integrated devices
Phase change microvalve for integrated devices
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DOI：
10.1021/ac0352934
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发表时间：
2004-07-01
影响因子：
7.4
通讯作者：
Burns, MA
中科院分区：
文献类型：
--
作者：
Pal, R;Yang, M;Burns, MA
已经开发了一种主动微阀，其使用可熔化活塞代替常规固体材料来阻碍微流体通道中的流体流动。这种相变阀操作简单，不需要额外的制造步骤。该阀门本身具有闭锁、可重复使用和防漏（至少250 psi）功能，并且可以使用电阻加热器进行电子寻址。该阀已被表征为一系列操作参数，这些参数将作为设计指南。对于所测试的设计，已经实现了在1秒内5 mm或更大的活塞位移。阀门1.4毫米的长度在一个50微米× 200微米的通道已被集成在一个生化反应装置，并成功地使用PCR的DNA扩增已经实现。相变阀可以容易地以阵列形式实现，该阵列形式可以用于实现复杂的微流体回路。
An active microvalve that uses a meltable piston in place of a conventional solid material to obstruct fluid flow in a microfluidic channel has been developed. This phase change valve is simple to operate and requires no additional fabrication steps. The valve is inherently latched, reusable, and leak-proof (to at least 250 psi) and can be electronically addressed using resistive heaters. The valve has been characterized for a range of operational parameters that will serve as a design guide. For the designs tested, piston displacements of 5 mm or more in 1 s have been achieved. Valves 1.4 mm in length in a 50 mum x 200 mum channel have been integrated on a biochemical reaction device, and successful DNA amplification using PCR has been achieved. The phase change valve can be easily implemented in an array format that can be used to realize complex microfluidic circuits.