Mouse Models for Type 1 Diabetes.
Mouse Models for Type 1 Diabetes.
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DOI：
10.1016/j.ddmod.2009.03.008
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发表时间：
2009
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20 世纪 70 年代末和 80 年代初 T1D 动物模型的发现推动了我们对 1 型糖尿病 (T1D) 的遗传学、病因学和发病机制的了解，特别是非肥胖糖尿病 (NOD) 小鼠。从那时起，转基因和基因靶向技术使得许多模型的遗传和致病复杂性降低。这些模型使研究人员能够放大这种复杂疾病的特定方面。在这篇综述中，我们概述了当前可用的 T1D 小鼠模型。
Our understanding of the genetics, aetiology and pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models of T1D in the late 1970s and early 1980s, particularly the non-obese diabetic (NOD) mouse. Since then, transgenic and gene-targeting technologies allowed the generation of many models with reduced genetic and pathogenic complexity. These models allowed researchers to zoom in on specific aspects of this complex disease. In this review, we provide an overview of currently available mouse models for T1D.