HIV-1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation.
HIV-1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation.
复制标题
HIV-1辅助调节蛋白Vpr促进含有L64P突变的Vpr突变体的泛素化和周转。
DOI：
10.1016/s0014-5793(04)00299-6
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发表时间：
2004
期刊：
影响因子：
3.5
通讯作者：
Zhu,Henghu
中科院分区：
文献类型：
--
作者：
Zhao,Ling-Jun;Jian,Heng;Zhu,Henghu
The auxiliary regulatory protein Vpr of HIV-1 possesses several biological activities which are believed to facilitate HIV-1 replication and pathogenesis. In this report, experimental evidence suggests a novel biological activity of Vpr: facilitation of the turnover of Vpr mutants bearing the L64P mutation. This novel activity of Vpr was shared by Vpr molecules from different subtypes of HIV-1. Co-expression of the wild type Vpr with the VprW54A/L64P mutant resulted in normal synthesis of the mutant mRNA but enhanced ubiquitination and turnover of the mutant protein. These results suggest that Vpr may interact with the ubiquitin/proteasome pathway to regulate the stability of viral or cellular proteins.
