FERTILITY IN MICE REQUIRES X-Y PAIRING AND A Y-CHROMOSOMAL SPERMIOGENESIS GENE-MAPPING TO THE LONG ARM
FERTILITY IN MICE REQUIRES X-Y PAIRING AND A Y-CHROMOSOMAL SPERMIOGENESIS GENE-MAPPING TO THE LONG ARM
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DOI：
10.1016/0092-8674(92)90509-b
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发表时间：
1992-10-30
期刊：
影响因子：
64.5
通讯作者：
PALMER, SJ
中科院分区：
文献类型：
--
作者：
BURGOYNE, PS;MAHADEVAIAH, SK;PALMER, SJ
越来越多的证据表明，哺乳动物的 Y 染色体除了其睾丸决定功能外，可能还具有其他男性限制功能，特别是在精子发生方面。我们之前已经证明，小鼠 Y 的短臂携带精原细胞增殖所需的信息。该信息与睾丸决定基因 Sry 一起包含在 Y 衍生的性逆转因子 Sxr(a) 中。然而，携带附着在 X 染色体上的 Sxr(a) 副本的 XO 雄性由于在减数分裂中期几乎完全停滞，因此是不育的。在这里，我们表明，可以通过为 XSxr(a) 染色体提供减数分裂配对伴侣（没有 Y 特异性 DNA）来克服这种减数分裂阻碍。然而，这并不能恢复生育能力，因为产生的精子都有异常的头部。结论是，小鼠Y染色体长臂的Y特异性区域包含精子头部正常发育所必需的信息。
There is accumulating evidence that the mammalian Y chromosome, in addition to its testis-determining function, may have other male limited functions, particularly in spermatogenesis. We have previously shown that the short arm of the mouse Y carries information needed for spermatogonial proliferation. This information, together with the testis-determining gene Sry, is contained within the Y-derived sex reversal factor Sxr(a). XO males carrying a copy of Sxr(a) attached to the X chromosome are nevertheless sterile owing to an almost complete arrest during the meiotic metaphase stages. Here we show that this meiotic block can be overcome by providing a meiotic pairing partner (with no Y-specific DNA) for the XSxr(a) chromosome. However, this does not restore fertility because the sperm produced all have abnormal heads. It is concluded that the Y-specific region of the mouse Y chromosome long arm includes information essential for the normal development of the sperm head.