Donor cell-derived acute myeloid leukemia after second allogenic cord blood transplantation in a patient with Fanconi anemia
Donor cell-derived acute myeloid leukemia after second allogenic cord blood transplantation in a patient with Fanconi anemia
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DOI：
10.1111/j.1399-3046.2011.01584.x
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发表时间：
2012-09-01
影响因子：
1.3
通讯作者：
Winiarski, Jacek
中科院分区：
文献类型：
--
作者：
Gustafsson, Britt;Moell, Jacob;Winiarski, Jacek
刘建军，刘建军，刘建军，等。急性髓系白血病的临床研究进展。儿科移植2011。(c) 2011 John Wiley & Sons A/S。摘要：据报道，造血干细胞移植后的DCL约占所有白血病复发的5%。有一些关于DCL的报道，主要是脐带血移植后的AML。在这个案例研究中，我们提出了一个被诊断为范可尼贫血的男孩，他接受了脐带血移植。由于移植失败，他在一个月后再次接受了移植，同样是脐带血移植。第二次移植两年后，他患上了急性髓性白血病，其中100%的细胞来自女性供体。捐献者是一名14岁的女性，最近被报道健康。
Gustafsson B, Moell J, LeBlanc K, Barbany G, Soderhall S, Winiarski J. Donor cell-derived acute myeloid leukemia after second allogenic cord blood transplantation in a patient with Fanconi anemia. Pediatr Transplantation 2011. (c) 2011 John Wiley & Sons A/S. Abstract: DCL following hematopoietic stem cell transplantation has been reported in approximately 5% of all leukemic relapses. There have been several reports on DCL, mainly AML after umbilical cord blood transplantation. In this case study, we present a young boy diagnosed with Fanconi anemia who underwent an umbilical cord blood transplantation. Because of the graft failure, he was retransplanted one month later, also with a cord blood transplant. Two years after the second transplant, he developed AML, where 100% of the cells were of female donor origin. The donor, a now 14-yr-old female, was recently reported healthy.