Magnetic field dependence of heating property of resovist? for magnetic hyperthermia
Magnetic field dependence of heating property of resovist? for magnetic hyperthermia
复制标题
Resovist 的加热特性与磁场相关吗？
DOI：
10.1002/tee.22848
复制
发表时间：
2019
影响因子：
1
通讯作者：
Mitobe Kazutaka
中科院分区：
文献类型：
--
作者：
Tonthat Loi;Yamamoto Yoshiyuki;Aki Fumitaka;Saito Hajime;Mitobe Kazutaka
Resovist®是一种MRI造影剂，由于其在磁热疗中作为治疗剂和在磁粒子成像中作为诊断剂的潜力而受到更多关注。在这项研究中，我们研究了通过操纵外加磁场的振幅和频率（H= 1.8-7.1 kA/m，f= 500 kHz，和H = 4.8 kA/m，f= 200-1000 kHz）的比吸收率（SAR）量化的热性能的依赖性。结果表明，SAR与振幅平方和频率成线性关系。此外，加热效率（例如，SAR = 44 W/g at H = 7.1 kA/m，f= 500 kHz）足以治疗肿瘤，这表明Resovist®用于热疗的有效性。这里获得的结果可能使我们能够找到施加磁场的最佳条件和治疗所需的Resovist®量。© 2018日本电气工程师协会。由John Wiley & Sons公司出版
Resovist®, a MRI contrast agent, has been gaining more attention due to its potential as a therapeutic agent in magnetic hyperthermia and a diagnostic agent in magnetic particle imaging. In this study, we examined the dependence of heating property quantified by the specific absorption rate (SAR) by manipulating the applied magnetic field amplitude and frequency (H= 1.8–7.1 kA/m,f= 500 kHz, andH= 4.8 kA/m,f= 200–1000 kHz). The results indicate that the SAR was linearly proportional to amplitude square and frequency. In addition, the heating efficiency (e.g., SAR = 44 W/g atH= 7.1 kA/m,f= 500 kHz) was sufficient to treat the tumor, which suggests the effectiveness of Resovist® for hyperthermia. The results obtained here may enable us to find the optimal conditions of applied magnetic field and the amount of Resovist® required for treatment. © 2018 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.