Dietary soybean enhances Pit-1 dependent pituitary hormone production in iodine deficient rats
Dietary soybean enhances Pit-1 dependent pituitary hormone production in iodine deficient rats
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DOI：
10.1007/s10735-005-4710-8
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发表时间：
2005-05-01
影响因子：
3.2
通讯作者：
Osamura, R
中科院分区：
文献类型：
--
作者：
Kajiya, H;Takekoshi, S;Osamura, R
报告显示大豆是致甲状腺肿的。在本研究中，我们研究了喂正常或缺碘食物的大鼠中高大豆饮食对垂体前叶激素产生调节的影响。碘缺乏单独导致甲状腺增生，血清甲状腺素水平降低，血清促甲状腺激素（TSH）增加的趋势。高大豆和低碘饮食（ID + DS）的组合协同作用，诱导甲状腺肥大，降低血清甲状腺素和三碘甲状腺原氨酸，并显着增加血清TSH。免疫组织化学分析显示，喂食ID + DS饲料的大鼠垂体TSH、催乳素（PRL）和生长激素（GH）产生细胞的数量显著增加。在ID + DS喂养大鼠中，参与TSH、PRL和GH基因表达的Pit-1也增加。这些结果表明，在缺碘动物中，高大豆制品饮食通过调节Pit-1诱导来调节垂体前叶激素的产生。
Reports have shown that soybeans are goitrogenic. In the present study, we investigated the effects of a high soybean diet in rats that were fed normal or iodine-deficient chow on the regulation of anterior pituitary hormone production. Iodine deficiency alone resulted in thyroid hyperplasia, reduced serum thyroxine levels, and a tendency towards an increase in serum thyroid stimulating hormone (TSH). The combination of a high soybean and low iodine diet (ID + DS) acted synergistically to induce thyroid hypertrophy, reduce serum thyroxine and tri-iodothyronine, and markedly increase serum TSH. Immunohistochemical analysis revealed that rats fed the ID + DS diet exhibited a marked increase in their number of pituitary TSH, prolactin (PRL), and growth hormone (GH) producing cells. Pituitary transcription factor-1 (Pit-1) which is involved in the expression of the TSH, PRL, and GH genes was also increased in ID + DS fed rats. These results suggest that a diet high in soybean products modulates anterior pituitary hormone production by regulating Pit-1 induction, in iodine-deficient animals.