Ruthenium half-sandwich complexes bound to protein kinase Pim-1
Ruthenium half-sandwich complexes bound to protein kinase Pim-1
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DOI：
10.1002/anie.200503468
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发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Meggers, E
中科院分区：
文献类型：
--
作者：
Debreczeni, JÉ;Bullock, AN;Meggers, E
(如图所示)半个三明治保持形状：与蛋白激酶Pim-1的ATP结合位点结合的微单分子有机钚抑制剂的结构(见图)表明，Ru中心在组织三维受体空间中的有机配体方面具有唯一的结构作用，从而产生与Pim-1的活性部位在形状和功能基团呈现上互补的结构。©2006 Wiley-VCH Verlag GmbH and Co.KGaA。
(Figure Presented) Keeping in shape with half a sandwich: The structure of a picomolar organoruthenium inhibitor bound to the ATP-binding site of the protein kinase Pim-1 (see picture) demonstrates that the ruthenium center has solely a structural role in organizing the organic ligands in the three-dimensional receptor space, thus yielding a structure that is complementary in shape and functional group presentation to the active site of Pim-1. © 2006 Wiley-VCH Verlag GmbH and Co. KGaA.