Mechanical properties of human atherosclerotic intima tissue
Mechanical properties of human atherosclerotic intima tissue
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DOI：
10.1016/j.jbiomech.2014.01.019
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发表时间：
2014-03-03
影响因子：
2.4
通讯作者：
Gijsen, Frank J. H.
中科院分区：
文献类型：
--
作者：
Akyildiz, Ali C.;Speelman, Lambert;Gijsen, Frank J. H.
冠状动脉和颈动脉粥样硬化斑块的进展和破裂是心肌梗死和中风的关键过程。生物力学应力分析计算斑块中的机械应力可以潜在地用于评估斑块易损性。应力分析强烈依赖于准确表示的机械性能的斑块components.In这篇综述中，内膜组织的组成，以及如何在斑块的发展过程中，从机械的角度进行了讨论。本文回顾了美国心脏协会的斑块分类方案，并对来自不同血管区域的斑块进行了比较，然后，概述了拉伸和压缩斑块内膜特性的实验研究，并将结果与动脉粥样硬化斑块的病理学联系起来。这一概述揭示了一个相当大的变化内的研究，和一个巨大的研究之间的分散。最后，在生物力学斑块建模的临床应用的实验数据的分散的影响。建议的机械测试协议的斑块组织和使用一个标准化的斑块classification schemes.This审查确定的知识斑块的机械性能和未来的步骤需要更好地了解斑块类型的具体材料的性能的现状。有了这样的理解，生物力学斑块建模可能最终为临床斑块风险分层提供必要的支持。(C)2014爱思唯尔有限公司版权所有。
Progression and rupture of atherosclerotic plaques in coronary and carotid arteries are the key processes underlying myocardial infarctions and strokes. Biomechanical stress analyses to compute mechanical stresses in a plaque can potentially be used to assess plaque vulnerability. The stress analyses strongly rely on accurate representation of the mechanical properties of the plaque components.In this review, the composition of intima tissue and how this changes during plaque development is discussed from a mechanical perspective. The plaque classification scheme of the American Heart Association is reviewed and plaques originating from different vascular territories are compared.Thereafter, an overview of the experimental studies on tensile and compressive plaque intima properties are presented and the results are linked to the pathology of atherosclerotic plaques. This overview revealed a considerable variation within studies, and an enormous dispersion between studies.Finally, the implications of the dispersion in experimental data on the clinical applications of biomechanical plaque modeling are presented. Suggestions are made on mechanical testing protocol for plaque tissue and on using a standardized plaque classification scheme.This review identifies the current status of knowledge on plaque mechanical properties and the future steps required for a better understanding of the plaque type specific material properties. With this understanding, biomechanical plaque modeling may eventually provide essential support for clinical plaque risk stratification. (C) 2014 Elsevier Ltd. All rights reserved.