The L-arginine nitric oxide pathway: avenue for a multiple-level approach to assess vascular function
The L-arginine nitric oxide pathway: avenue for a multiple-level approach to assess vascular function
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DOI：
10.1515/bc.2006.168
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发表时间：
2006-10-01
影响因子：
3.7
通讯作者：
Kelm, Malte
中科院分区：
文献类型：
--
作者：
Rassaf, Tienush;Kleinbongard, Petra;Kelm, Malte
内皮功能障碍是动脉粥样硬化的早期阶段，并已被归因于受损的一氧化氮（NO）生物活性和氧源性自由基的形成增加。由于内皮功能障碍至少部分是可逆的，因此评估NO可用性的改变具有重要的诊断和预后意义。识别这些变化可能有助于针对无症状的人谁是心血管疾病的风险，并可能受益于预防措施。聚焦于一个单一的信号通路，我们在这里提出了一个多层次的方法，通过评估血管壁的分子，生化，结构和功能的变化，早期诊断心血管疾病。
Endothelial dysfunction is an early stage of atherosclerosis and has been attributed to impaired nitric oxide (NO) bioactivity and enhanced formation of oxygen-derived free radicals. Given that endothelial dysfunction is at least in part reversible, the assessment of altered NO availability is of important diagnostic and prognostic significance. Identification of such alterations may help to target asymptomatic individuals who are at risk for cardiovascular diseases and would likely benefit from preventive measures. Focusing on a single signaling pathway, we present here a multi-level approach for the early diagnosis of cardiovascular diseases by assessing molecular, biochemical, structural, and functional changes in the vascular wall.