Lack of association between ACE gene insertion/deletion polymorphism and elite artistic gymnastic performance of Italian gymnasts
Lack of association between ACE gene insertion/deletion polymorphism and elite artistic gymnastic performance of Italian gymnasts
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ACE基因插入/缺失多态性与意大利体操运动员的精英艺术体操表现之间缺乏关联
DOI：
10.1080/17461391.2010.499971
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发表时间：
2011
影响因子：
3.2
通讯作者：
C. Calo
中科院分区：
文献类型：
--
作者：
M. Massidda;G. Vona;C. Calo
摘要血管紧张素转换酶（ACE）基因多态性是人类运动能力领域研究最多的遗传标记。关于ACE基因型与精英运动员地位之间可能的关联，文献中一直存在争议。事实上，尽管最近的研究没有发现来自混合运动学科的运动员有显著的关联，但其他研究人员认为插入（I）变异可能与精英耐力表现有关，而缺失（D）变异可能在精英短跑运动员中过度存在。本研究的目的是确定，第一次，ACE基因型和短跑运动员之间的关系，在意大利优秀体操运动员的地位。为了验证这一假设，我们评估了33名优秀的意大利体操运动员（17名男性，16名女性）和对照组的53名（31名男性，22名女性）无关久坐的个人。使用口腔拭子从每个参与者中提取DNA，并使用PCR确定ACE I/D多态性，同时使用琼脂糖凝胶电泳和溴化乙锭染色检测不同扩增片段。体操运动员ACE基因型和等位基因频率（DD、ID、II分别为0.39、0.48、0.12; D等位基因=0.64）与意大利久坐对照组（DD、ID、II分别为0.39、0.45、0.15; D等位基因=0.62）无显著差异。然而，我们的对照组的频率是相似的，在意大利久坐的个人样本中观察到的，和其他作者报道的一般高加索人群的不同。此外，我们的对照组的频率与其他涉及优秀短跑运动员的协会研究报告的频率没有差异。我们的研究结果表明，缺乏关联的ACE I/D多态性和优秀体操表现在意大利人。
Abstract The angiotensin converting enzyme (ACE) polymorphism is the most studied genetic marker in the field of human performance. There is a continuing debate in the literature regarding the possible association of ACE genotypes and elite athletic status. In fact, despite recent studies having identified no significant associations in athletes from mixed sporting disciplines, other researchers suggest that the insertion (I) variant may be associated with elite endurance performance, and the deletion (D) variant can be over-represented among elite sprinters. The purpose of the present study was to determine, for the first time, the association between the ACE genotypes and sprint athlete status among elite Italian gymnasts. To test this hypothesis, we assessed 33 elite Italian gymnasts (17 males, 16 females) and a control group of 53 (31 males, 22 females) unrelated sedentary individuals. DNA was extracted from each participant using a buccal swab and the ACE I/D polymorphism was determined using PCR while different amplified fragments were detected by electrophoresis using agarose gel and ethidium bromide staining. The ACE genotypes and allele frequencies among gymnasts (DD, ID, II=0.39, 0.48, 0.12, respectively; D allele=0.64) were not significantly different from those of Italian sedentary controls (DD, ID, II=0.39, 0.45, 0.15, respectively; D allele=0.62). However, the frequencies of our control group were similar to those observed in a sample of Italian sedentary individuals, and different to those of the general Caucasian population reported by other authors. Furthermore, the frequencies of our control group did not differ from those reported in other association studies involving elite sprint athletes. Our results suggest a lack of association between the ACE I/D polymorphism and elite gymnastics performance in Italians.
影响因子：
37.8
作者：
L. Murphey;J. Gainer;D. Vaughan;N. Brown
通讯作者：
L. Murphey;J. Gainer;D. Vaughan;N. Brown