Studies on the constituents of Leonurus sibiricus L.
Studies on the constituents of Leonurus sibiricus L.
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DOI：
10.1248/cpb.51.341
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发表时间：
2003-03-01
影响因子：
1.7
通讯作者：
Fujimoto, Y
中科院分区：
文献类型：
--
作者：
Satoh, M;Satoh, Y;Fujimoto, Y
从益母草地上部分分离出两种新的呋喃二萜内酯 LS-1 (1) 和 LS-2 (2)，以及四种已知的呋喃二萜内酯 3、4、5 和 6。通过光谱方法确定了新化合物的结构。这里分离的化合物1-6对组织培养中的白血病细胞(L 1210)表现出中等的细胞毒活性(IC50=50-60μg/ml)。
Two new furanoditerpene-lactones, LS-1 (1) and LS-2 (2), were isolated along with four known furanoditerpene-lactones 3, 4, 5 and 6 from the aerial part of Leonurus sibiricus L. The structures of the new compounds were determined by spectroscopic means. Compounds 1-6 isolated here exhibited moderate cytotoxic activity (IC50=50-60 mug/ml) against leukemia cells (L 1210) in tissue culture.