Valid symptom reporting at upper endoscopy in a random sample of the Swedish adult general population:: the Kalixanda study
Valid symptom reporting at upper endoscopy in a random sample of the Swedish adult general population:: the Kalixanda study
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DOI：
10.1080/00365520410008141
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发表时间：
2004-12-01
影响因子：
1.9
通讯作者：
Agréus, L
中科院分区：
文献类型：
--
作者：
Aro, P;Ronkainen, J;Agréus, L
背景：上食道胃十二指肠镜检查被认为是评估上消化道疾病的金标准，但目前很少用于流行病学研究。一个令人担忧的问题是，这一程序可能会对普通成年人口中的志愿者进行抽样产生偏差。这项研究的目的是探索该程序是否会影响症状报告。方法：从瑞典两个直辖市(n=21,610)随机抽取3000名20-81岁(平均年龄50.4岁)的成年人，采用有效的邮寄问卷(腹部症状问卷)评估胃肠道症状。随机邀请应答者中的一小部分人接受上消化道内窥镜检查，并使用相同的问卷重复症状报告，以及幽门螺杆菌的血清学测试。结果：初始问卷应答率为74.2%，符合上消化道镜检者参与率为73.3%(1001例，平均年龄54.0岁，男性48.8%)。在选择过程中没有遇到重大的社会或症状抽样错误，除了最年轻的受试者中有过多的症状报告人。反流症状、消化不良症状和肠易激症状的发生率分别为40%、37.6%和29.6%，虽较高，但并非极端。结论：高位内窥镜检查策略是成功的。应答率很高，没有临床相关性的重大选择偏差。为这项研究选择的队列似乎代表了瑞典成年人的总体情况。
Background: Upper oesophagogastroduodenoscopy is considered to be the gold standard for upper gastrointestinal disease assessment, but is currently seldom used in epidemiological studies. One concern is that the procedure may bias sampling among volunteers in a general adult population. The aim of this study was to explore whether the procedure affects symptom reporting. Methods: A random sample of 3000 adults aged 20 - 81 years ( mean age 50.4), from two Swedish municipalities (n = 21,610) was surveyed using a validated postal questionnaire ( the Abdominal Symptom Questionnaire) assessing gastrointestinal symptoms. A subsample of the responders was invited, in random order, to undergo an upper endoscopy and repeated symptom reporting using the same questionnaire, as well as a serology test for Helicobacter pylori. Results: The response rate to the initial questionnaire was 74.2% and the participation rate for those eligible for the upper endoscopy was 73.3% ( n = 1001, mean age 54.0 years, 48.8% male). No major social or symptom sampling error was encountered from the selection process, with the exception of an excess of symptom reporters among the youngest subjects. The prevalence of reflux symptoms, dyspeptic symptoms and irritable bowel symptoms was 40%, 37.6% and 29.6%, respectively, which is relatively high, but in no way extreme. Conclusions: The upper endoscopy survey strategy was successful. The response rate was high and there was no major selection bias of clinical relevance. The cohort selected for this study appears to be representative of the general Swedish adult population.