Valproate prescription prevalence among women of childbearing age.
Valproate prescription prevalence among women of childbearing age.
复制标题
育龄妇女中丙戊酸钠处方流行率。
DOI：
10.1176/ps.62.2.pss6202_0218
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Essock,SusanM
中科院分区：
文献类型：
--
作者：
Wisner,KatherineL;Leckman-Westin,Emily;Finnerty,Molly;Essock,SusanM
丙戊酸钠与多囊卵巢综合征以及产前暴露婴儿的先天性畸形和发育迟缓相关。使用丙戊酸盐的育龄妇女的精神健康状况的频率determined.MethodsUsing纽约州医疗补助索赔精神疾病的人，40,526个人的积极处方情绪稳定剂（非抗精神病药）在2009年5月1日，被确定。卡方检验比较使用丙戊酸盐育龄妇女与年龄相仿的男性和老年women. Results丙戊酸盐是最常见的处方药的年轻女性（23.4%）。男性比女性更有可能，老年女性比年轻女性更有可能，服用丙戊酸盐。ConclusionsOver 20%的育龄妇女接受情绪稳定剂与丙戊酸盐治疗，虽然越来越多的数据对这种药物的生殖毒性迫使考虑其他非抗精神病情绪稳定剂作为一线选择。（Psychiatric Services 62：218-220，2011）
ObjectiveValproate is associated with polycystic ovary syndrome as well as congenital malformations and developmental delays of infants who were prenatally exposed. The frequency of valproate use for mental health conditions among women of childbearing age was determined.MethodsUsing New York State Medicaid claims for persons with psychiatric disorders, 40,526 individuals with active prescriptions for mood stabilizers (non-antipsychotic) on May 1, 2009, were identified. Chi square tests were used to compare valproate use among women of childbearing age with similarly aged men and older women.ResultsValproate was the most commonly prescribed agent for young women (23.4%). Men were more likely than women, and older women more likely than younger women, to take valproate.ConclusionsOver 20% of childbearing-aged women receiving mood stabilizers were treated with valproate, although increasing data on the reproductive toxicity of this agent compel consideration of other non-antipsychotic mood stabilizers as first-line choices. (Psychiatric Services62:218–220, 2011)