EB-radiolysis of carbamazepine: in pure-water with different ions and in surface water
EB-radiolysis of carbamazepine: in pure-water with different ions and in surface water
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DOI：
10.1007/s10967-014-3322-8
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发表时间：
2014-07
影响因子：
1.6
通讯作者：
M. Zheng;Gang Xu;Jing-cheng Pei;Xiangxin He;Peimin Xu;Ning Liu;Minghong Wu
中科院分区：
文献类型：
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作者：
M. Zheng;Gang Xu;Jing-cheng Pei;Xiangxin He;Peimin Xu;Ning Liu;Minghong Wu
本文研究了卡马西平在不同离子的纯水和地表水中的电子束辐解特性。结果表明，·OH、·H和EAQ−均对CBZEB的降解起作用，其中·OH起重要作用。酸性溶液有利于CBZ的降解，碱性环境对CBZ的降解有抑制作用。HSO4-和SO32−促进了CBZ的降解，而CO32−、NO2−、NO3−、NH4+和Cl−对降解有抑制作用。在地表水中，EB辐解是降解卡马西平的有效途径；在EB辐射过程中，卡马西平可能以三种不同的方式演化：被EAQ−和·H(中间体10，11-二氢-10-11-环氧卡马西平(I))还原，被·OH(中间体10，11-二氢-10-11-环氧卡马西平(II)和2(3)-羟基卡马西平(III))氧化，水合生成10，11-二氢-10-羟基卡马西平(IV)，最终中间产物都被矿化成CO_2、H_2O、N_2和NH_4+。这些结果有助于研究药物在地表水中的电子束辐解。
The electron beam (EB) radiolysis characteristics of carbamazepine (CBZ) in pure-water with different ions and that in surface water were studied in this paper. It suggested that the ·OH, ·H and eaq−all played roles on CBZ EB degradation, and the ·OH played the vital role. Acidic solution was favorable for CBZ degradation, while alkaline environment inhibited it. HSO4–and SO32−enhanced the CBZ degradation, but CO32−, NO2−, NO3−NH4+and Cl−inhibited. In surface water, the EB-radiolysis was an effective way to degrade CBZ; and CBZ might evolve in three different ways during EB radiation: reduction by eaq−and ·H (intermediate 10,11-dihydrocarbamazepine (I)), oxidization by ·OH (intermediates 10,11-dihydro-10-11-expoxycarbamazepine (II) and 2(3)-hydroxycarbamazepine (III)) and hydration into 10,11-dihydro-10-hydroxycarbamazepine (IV) and finally the intermediates were all mineralized into CO2, H2O, N2and NH4+. All the results contribute to study the EB-radiolysis of pharmaceuticals in surface water.