Frequency of dementia in Parkinson disease
Frequency of dementia in Parkinson disease
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DOI：
10.1001/archneur.1996.00550060082020
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发表时间：
1996-06-01
影响因子：
--
通讯作者：
Cummings, JL
中科院分区：
文献类型：
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作者：
Aarsland, D;Tandberg, E;Cummings, JL
目的：探讨帕金森病（PD）患者痴呆的发生率。设计：基于社区的患病率研究。环境：研究人群包括来自挪威罗加兰县的220858名居民。参与者：近400名参与者接受了神经科医生的检查，其中245人被诊断为帕金森病，并被纳入研究。测量方法：用简易精神状态测验评定心理功能；Gottfries， Brane和Steen量表；以及统一帕金森氏症评定量表的智力子量表。在半结构化访谈中，采用了《精神障碍诊断与统计手册》第三版修订版中的标准来确定痴呆的诊断。结果：痴呆67例（27.7%）。痴呆患者在研究时和PD发病时年龄较大，并且比无痴呆患者患PD的时间更长。重度抑郁在痴呆患者（23%）中比在无痴呆患者（2.3%）中更常见(chi(2)， P
Objective: To investigate the frequency of dementia in patients with Parkinson disease (PD).Design: Community-based prevalence study.Setting: The study population comprised 220 858 inhabitants from the Rogaland County, Norway.Participants: Almost 400 participants were examined by a neurologist, and 245 were given the diagnosis of PD and included in the study.Measurements: Mental functioning was rated with the Mini-Mental State Examination; Gottfries, Brane, and Steen scale; and the intellectual subscale of the Unified Parkinson's Disease Rating Scale. Criteria from the Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, were applied during a semistructured interview to determine the diagnosis of dementia.Results: Dementia was found in 67 patients (27.7%). Patients with dementia were older at the time of the study and at onset of PD and had had PD longer than the patients without dementia. Major depression was more common among patients with dementia (23%) than among patients without dementia (2.3%) (chi(2), P