Strategies for Personalized Medicine-Based Research and Implementation in the Clinical Workflow
Strategies for Personalized Medicine-Based Research and Implementation in the Clinical Workflow
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DOI：
10.1038/clpt.2012.119
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发表时间：
2012-10-01
影响因子：
6.7
通讯作者：
Kroemer, H. K.
中科院分区：
文献类型：
--
作者：
Lieb, W.;Voelzke, H.;Kroemer, H. K.
人类基因组的解码，通过高通量技术的发展来获得大规模的分子数据（例如，遗传变异、转录水平和代谢物浓度的信息）为了解常见疾病的分子基础和药物反应变异的原因提供了新的见解。本文提出了将这些新知识纳入研究和临床工作流程的策略。
The decoding of the human genome, paralleled by the development of high-throughput technologies to obtain large-scale molecular data (e.g., information on genetic variations, transcription levels, and metabolite concentrations) is providing new insights into the molecular basis of common diseases and the causes of variability in drug response. This article presents strategies to incorporate this new knowledge into research and clinical workflow.