Temporal trends in stroke incidence and case-fatality rates in Arcadia, Greece: A sequential, prospective, population-based study
Temporal trends in stroke incidence and case-fatality rates in Arcadia, Greece: A sequential, prospective, population-based study
复制标题
DOI：
10.1177/1747493021995594
复制
发表时间：
2021-02-24
影响因子：
6.7
通讯作者：
Ntaios, George
中科院分区：
文献类型：
--
作者：
Karantali, Eleni;Vemmos, Konstantinos;Ntaios, George
背景 据报道，在过去几十年中，高收入国家的中风发病率和病死率有所下降。流行病学研究对于卫生服务部门制定预防和治疗策略非常重要。目的这项基于人群的研究的目的是确定希腊南部阿卡迪亚地区中风发病率和首次中风病死率的时间趋势。方法在三个研究期间（从 11 月开始），使用相同的标准和多个重叠来源来确定阿卡迪亚地区的所有首次中风病例。 1993年至1995年10月； 2004年；以及 2015-2016 年。使用泊松回归比较粗略的发病率和根据欧洲人口进行年龄调整的发病率。使用相同的方法估计并比较 28 天的病死率。结果总共确定了 1315 名首次中风患者。 1993/1995年欧洲人口的年龄标准化发病率为每10万人年252例（95% CI 231-239），2004年为252例（95% CI 223-286），2015/2016年为211例（192-232）。经年龄和性别调整后的总体发病率下降了 16%（发病率比 0.84，95% CI：0.72-0.97）。同样，28 天病死率下降了 28%（病死率 = 0.72，95% CI：0.58-0.90）。结论这项基于人群的研究报告称，1993 年至 2016 年间，希腊南部的中风发病率和死亡率显着下降。
BackgroundStroke incidence and case-fatality are reported to decline in high-income countries during the last decades. Epidemiological studies are important for health services to organize prevention and treatment strategies.AimsThe aim of this population-based study was to determine temporal trends of stroke incidence and case-fatality rates of first-ever stroke in Arcadia, a prefecture in southern Greece.MethodsAll first-ever stroke cases in the Arcadia prefecture were ascertained using the same standard criteria and multiple overlapping sources in three study periods: from November 1993 to October 1995; 2004; and 2015-2016. Crude and age-adjusted to European population incidence rates were compared using Poisson regression. Twenty-eight days case fatality rates were estimated and compared using the same method.ResultsIn total, 1315 patients with first-ever stroke were identified. The age-standardized incidence to the European population was 252 per 100,000 person-years (95% CI 231-239) in 1993/1995, 252 (95% CI 223-286) in 2004, and 211 (192-232) in 2015/2016. The overall age- and sex-adjusted incidence rates fell by 16% (incidence rates ratio 0.84, 95% CI: 0.72-0.97). Similarly, 28-day case-fatality rate decreased by 28% (case fatality rate ratio = 0.72, 95% CI: 0.58-0.90).ConclusionsThis population-based study reports a significant decline in stroke incidence and mortality rates in southern Greece between 1993 and 2016.