Effects of xylazine on ventilation in horses.
Effects of xylazine on ventilation in horses.
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赛拉嗪对马通气的影响。
DOI：
10.2460/ajvr.1992.53.06.916
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发表时间：
1992
影响因子：
1
通讯作者：
C. Kurpershoek
中科院分区：
文献类型：
--
作者：
J. Lavoie;John Pascoe;C. Kurpershoek
研究了3种常用剂量(0.3、0.5、1.1 mg/kg体重)的赛拉津对6只纯种白兔呼吸功能的影响。所有剂量的赛拉津都会改变呼吸模式，当剂量为1.1 mg/kg时，马会出现持续7到70秒的呼吸暂停。给药后呼吸频率、分钟血容量和动脉血氧分压(PaO_2)随给药时间的延长而显著降低(P<0.001)，但不同剂量间无显著差异。注药后1分钟潮气量逐渐增加，注药后5分钟潮气量显著大于注药前(P<0.01)。动脉血二氧化碳分压(PaCO2)无明显升高。给药1.1 mg/kg后，戴面罩和不戴口罩测得PaO2平均最大降幅分别为28.2+/-8.7 mm和22.2+/-4.9 mm。同样，佩戴口罩和不戴面罩测得的PaCO2平均最大增幅分别为4.5+/-2.3 mm和4.2+/-2.4 mm。口罩的使用和时间之间的显著交互作用没有被检测到，尽管当马不戴口罩时，PaO2的变化略有减弱。当呼吸不足或要进行肺功能测试时，在选择镇静剂时，应考虑赛拉津对马呼吸功能的暂时影响。
The effects of 3 commonly used dosages (0.3, 0.5, and 1.1 mg/kg of body weight, IV) of xylazine on ventilatory function were evaluated in 6 Thoroughbred geldings. Altered respiratory patterns developed with all doses of xylazine, and horses had apneic periods lasting 7 to 70 seconds at the 1.1 mg/kg dosage. Respiratory rate, minute volume, and partial pressure of oxygen in arterial blood (PaO2) decreased significantly (P less than 0.001) with time after administration of xylazine, but significant differences were not detected among dosages. After an initial insignificant decrease at 1 minute after injection, tidal volume progressively increased and at 5 minutes after injection, tidal volume was significantly (P less than 0.01) greater than values obtained before injection. Partial pressure of carbon dioxide in arterial blood (PaCO2) was insignificantly increased. After administration of xylazine at a dosage of 1.1 mg/kg, the mean maximal decrease in PaO2 was 28.2 +/- 8.7 mm of Hg and 22.2 +/- 4.9 mm of Hg, measured with and without a respiratory mask, respectively. Similarly, the mean maximal increase in PaCO2 was 4.5 +/- 2.3 mm of Hg and 4.2 +/- 2.4 mm of Hg, measured with and without the respiratory mask, respectively. Significant interaction between use of mask and time was not detected, although the changes in PaO2 were slightly attenuated when horses were not masked. The temporal effects of xylazine on ventilatory function in horses should be considered in selecting a sedative when ventilation is inadequate or when pulmonary function testing is to be performed.