Rotavirus Vaccines in Belgium Policy and Impact
Rotavirus Vaccines in Belgium Policy and Impact
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DOI：
10.1097/inf.0b013e3181fefc51
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发表时间：
2011-01-01
影响因子：
3.6
通讯作者：
Van Damme, Pierre
中科院分区：
文献类型：
--
作者：
Braeckman, Tessa;Van Herck, Koen;Van Damme, Pierre
背景：目前比利时轮状病毒疫苗接种的经验为观察疫苗接种的效果提供了一个独特的视角。在引进后不久，发布了一项全国性的建议，尽管这两种轮状病毒疫苗都是通过部分报销提供的，但疫苗接种已经达到了很高的水平（至少90%）。方法：为了观察比利时轮状病毒疫苗接种政策的有效性，在实施3年后，我们回顾性地整理了有关实验室数量的公开数据，1999年至2010年期间向国家哨点实验室网络报告的确诊轮状病毒病例，并将其与以下方面的现有数据进行比较：结果：两个数据来源（向哨点网络报告的实验室诊断病例以及因轮状病毒胃肠炎住院的数据）显示，轮状病毒感染数量减少，发病延迟4至6周，发病高峰在接种后时期。由于这种下降与疫苗接种增加相一致，并且在连续的轮状病毒季节持续，因此这种影响主要归因于轮状病毒疫苗接种。尽管部分疫苗费用得到偿还，但疫苗覆盖率迅速增加，这是令人瞩目的。有必要继续进行许可后监测，以进一步调查疫苗的有效性，并记录疫苗接种对减少疾病负担的公共卫生影响。
Background: The current Belgian experience with rotavirus vaccination provides a unique perspective to look at the effect of vaccination. Shortly after introduction, a nation-wide recommendation was issued and despite the fact that both rotavirus vaccines are offered through partial reimbursement, vaccine uptake has already reached a high level (at least 90%).Methods: For the purpose of looking at the effectiveness of the Belgian rotavirus vaccination policy, 3 years after introduction, we retrospectively collated the publicly available data on the number of laboratory-confirmed rotavirus cases reported to a national network of sentinel laboratories during 1999 to 2010 and compared them with the available data on hospitalizations due to rotavirus gastroenteritis.Results: Both data sources (reported laboratory-diagnosed cases to a sentinel network as well as data on hospitalizations due to rotavirus gastroenteritis) show a decrease in the number of rotavirus infections and a 4- to 6-week delay in the onset of disease and the peak of incidence in the postvaccination period.Conclusions: Because this decline coincides with the increased vaccine uptake and is sustained during consecutive rotavirus seasons, the effect is mainly attributed to the rotavirus vaccination. The rapid increase in vaccine coverage, despite the partial reimbursement for the vaccines, is remarkable. Continued postlicensure surveillance is necessary to further investigate the effectiveness of the vaccines and to document the public health impact of the vaccination in reducing disease burden.