Acupoint-specific fMRI patterns in human brain
Acupoint-specific fMRI patterns in human brain
复制标题
人脑中穴位特异性功能磁共振成像模式
DOI：
10.1016/j.neulet.2005.04.021
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发表时间：
2005-08-05
影响因子：
2.5
通讯作者：
Tang, XW
中科院分区：
文献类型：
--
作者：
Yan, B;Li, K;Tang, XW
中枢神经系统（CNS）对针灸的特异性反应最近引起了人们的关注。重要的是要了解针灸在一个穴位和附近的“假”点所诱发的脑功能磁共振成像图像的差异。在这里，我们报告了37名健康志愿者对Liv3（太中）和LI4（合谷）与假针穴的脑功能磁共振成像图像的分析。我们发现，与假穴位针刺相比，Liv3或LI4针刺在颞中回和小脑中有共同的激活区，同时在额中回和顶叶下小叶中有共同的失活区。针刺Liv3可诱发中央后回、扣带后端、海马旁回、ba7、ba19和ba11的特异性激活，但与针刺其假点相比，在额下回、扣带前端、ba17和ba18的特异性失活。针刺LI4诱发了颞极特异性激活，但与针刺其假点相比，在中央前回、颞上回、枕回和ba8、9和45失活。这些观察结果表明，针刺穴位会诱发特定的大脑活动模式，而这些模式可能与针灸的治疗效果有关。2005爱思唯尔爱尔兰有限公司版权所有。
Specific central nervous system (CNS) responses to acupuncture have recently attracted attention. It is important to understand the differences in fMRI images of the brain evoked by acupuncture at an acupoint and at a nearby "sham" point. Here, we report analyses of fMRI images of the brains of 37 healthy volunteers in response to acupuncture at Liv3 (Taichong) and LI4 (Hegu) versus their sham points. We found common activation areas in response to Liv3 or LI4 acupuncture in the middle temporal gyrus and cerebellum, along with deactivation areas in the middle frontal gyrus and inferior parietal lobule, compared with the effects of acupuncture at sham points. Acupuncture at Liv3 evoked specific activation at the postcentral gyrus, posterior cingulate, parahippocampal gyrus, BA 7, 19 and 4 1, but deactivation at the inferior frontal gyrus, anterior cingulate, BA 17 and 18, compared with acupuncture at its sham point. Acupuncture at LI4 evoked specific activation at the temporal pole, but deactivation at the precentral gyrus, superior temporal gyrus, pulvinar and BA 8, 9 and 45, compared with acupuncture at its sham point. These observations reveal that acupuncture at acupoints induces specific patterns of brain activity, and these patterns may relate to the therapeutic effects of acupuncture. (c) 2005 Elsevier Ireland Ltd. All rights reserved.