Neuroinflammation as measured by positron emission tomography in patients with recent onset and established schizophrenia: implications for immune pathogenesis.
Neuroinflammation as measured by positron emission tomography in patients with recent onset and established schizophrenia: implications for immune pathogenesis.
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DOI：
10.1038/s41380-020-0829-y
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发表时间：
2021-09
影响因子：
11
通讯作者：
Talbot PS
中科院分区：
文献类型：
--
作者：
Conen S;Gregory CJ;Hinz R;Smallman R;Corsi-Zuelli F;Deakin B;Talbot PS
正电子发射断层扫描（PET）成像的18 kDa的转运蛋白（TSPO），这是上调激活小胶质细胞，是一种方法，用于调查是否免疫激活是明显的成年人的大脑中精神分裂症。本研究旨在测量迄今为止最大患者组中TSPO的可用性，并比较新近发作（ROS）和确诊（ES）精神分裂症患者的TSPO可用性。总共有20名ROS患者（14名男性）、21名ES患者（13名男性）和21名健康对照完成了研究。患者主要接受抗精神病药物治疗。参与者使用TSPO特异性放射性配体[11 C]（R）-PK11195进行PET扫描。主要结果是前扣带皮层（ACC）的结合电位（BPND）。次要结局是其他6个地区的BPND。研究了TSPO可用性和症状严重程度之间的相关性。数据显示，老年人（ES和对照组）的平均BPND高于年轻人（ROS和对照组），但ROS或ES与其各自年龄匹配的对照组之间无显著差异（ACC;诊断的ANOVA主效应：F1，58 = 0.407，p = 0.526）。与对照组相比，BPND在无抗精神病药（n = 6）中较低，但在药物治疗的ROS患者中则不然。ES组BPND与阳性症状评分呈负相关，与阴性症状评分呈正相关。我们的数据表明，年龄与较高的TSPO有关，但精神分裂症的诊断则无关。相反，在无药物的近期发作患者中低于正常的TSPO水平可能意味着小胶质细胞发育和/或功能受损，这可以通过抗精神病药物治疗来抵消。需要开发用于特异性免疫机制的新型放射性配体以进一步澄清。
Positron emission tomography (PET) imaging of the 18 kDa translocator protein (TSPO), which is upregulated in activated microglia, is a method for investigating whether immune activation is evident in the brain of adults with schizophrenia. This study aimed to measure TSPO availability in the largest patient group to date, and to compare it between patients with recent onset (ROS) and established (ES) schizophrenia. In total, 20 ROS patients (14 male), 21 ES (13 male), and 21 healthy controls completed the study. Patients were predominantly antipsychotic-medicated. Participants underwent a PET scan using the TSPO-specific radioligand [11C](R)-PK11195. The primary outcome was binding potential (BPND) in the anterior cingulate cortex (ACC). Secondary outcomes were BPND in six other regions. Correlations were investigated between TSPO availability and symptom severity. Data showed that mean BPND was higher in older (ES and controls) compared with younger (ROS and controls) individuals, but did not significantly differ between ROS or ES and their respective age-matched controls (ACC; ANOVA main effect of diagnosis: F1,58 = 0.407, p = 0.526). Compared with controls, BPND was lower in antipsychotic-free (n = 6), but not in medicated, ROS patients. BPND in the ES group was negatively correlated with positive symptoms, and positively correlated with negative symptom score. Our data suggest ageing is associated with higher TSPO but a diagnosis of schizophrenia is not. Rather, subnormal TSPO levels in drug-free recent-onset patients may imply impaired microglial development and/or function, which is counteracted by antipsychotic treatment. The development of novel radioligands for specific immune-mechanisms is needed for further clarification.
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DOI：
10.1177/0271678x17710182
发表时间：
2017-08
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Owen DR;Narayan N;Wells L;Healy L;Smyth E;Rabiner EA;Galloway D;Williams JB;Lehr J;Mandhair H;Peferoen LA;Taylor PC;Amor S;Antel JP;Matthews PM;Moore CS
通讯作者：
Moore CS
影响因子：
6.6
作者：
Kenk, Miran;Selvanathan, Thiviya;Mizrahi, Romina
通讯作者：
Mizrahi, Romina
影响因子：
6.6
作者：
Marsman, Anouk;van den Heuvel, Martijn P.;Pol, Hilleke E. Hulshoff
通讯作者：
Pol, Hilleke E. Hulshoff
自闭症谱系障碍（ASD）、精神分裂症和双相情感障碍中全转录组异构体水平失调
影响因子：
56.9
作者：
Gandal, Michael J.;Zhang, Pan;Geschwind, Daniel H.
通讯作者：
Geschwind, Daniel H.
影响因子：
--
作者：
Lieberman, JA;Tollefson, GD;Tohen, M
通讯作者：
Tohen, M