High-frequency ultrasound point-of-care device to quantify myopia-induced microstructural changes in the anterior sclera.
High-frequency ultrasound point-of-care device to quantify myopia-induced microstructural changes in the anterior sclera.
复制标题
高频超声护理点设备可量化近视引起的前巩膜微观结构变化。
DOI：
10.1111/opo.13122
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Mamou,Jonathan
中科院分区：
文献类型：
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作者：
Hoerig,Cameron;Hoang,QuanV;Aichele,Johannes;Catheline,Stefan;Mamou,Jonathan
目的开发一种利用高频超声(US)评估近视相关前巩膜微结构变化的POC设备。方法POC设备必须满足四个基本要求：测量组件手持；软件必须简单并提供实时反馈；必须满足相关管理机构提出的患者安全和健康数据安全要求，测量数据必须具有足够的信噪比(SNR)和可重复性。POC设备获取的射频回波数据将使用我们的定量超声方法进行处理，以表征组织的微结构和生物力学特性。结果所开发的POC设备满足了所有规定的要求。高频换能器安装在定制的3D打印笔状支架中，可以方便地测量前巩膜。定制软件为数据采集、实时数据显示和安全数据存储提供了一个简单的界面。美国压力场的暴露测量表明，设备符合美国食品和药物管理局对美国眼科的限制。对志愿者的活体测量表明，射频数据的信噪比和采集一致性适合于定量分析。结论建立了一种使用高频超声的全功能POC装置，用于评价前巩膜的微结构。使用POC设备扫描近视患者眼睛的计划研究将有助于阐明近视对前巩膜微结构的影响。如果有效，这种便携、廉价、用户友好的系统可能会成为常规眼科检查的重要组成部分。
PurposeTo develop a point‐of‐care (POC) device using high‐frequency ultrasound (US) for evaluating microstructural changes in the anterior sclera associated with myopia.MethodsThe proposed POC device must satisfy four primary requirements for effective clinical use: the measurement component is handheld; the software must be simple and provide real‐time feedback; patient safety and health data security requirements set forth by relevant governing bodies must be satisfied and the measurement data must have sufficient signal‐to‐noise ratio (SNR) and repeatability. Radiofrequency (RF) echo data acquired by the POC device will be processed using our quantitative US methods to characterise tissue microstructure and biomechanical properties.ResultsAll stated requirements have been met in the developed POC device. The high‐frequency transducer is housed in a custom, 3D‐printed, pen‐like holder that allows for easy measurements of the anterior sclera. Custom software provides a simple interface for data acquisition, real‐time data display and secure data storage. Exposimetry measurements of the US pressure field indicate device compliance with United States Food and Drug Administration limits for ophthalmic US. In vivo measurements on a volunteer suggest the RF data SNR and acquisition consistency are suitable for quantitative analysis.ConclusionsA fully functioning POC device using high‐frequency US has been created for evaluating the microstructure of the anterior sclera. Planned studies using the POC device to scan the eyes of myopia patients will help clarify how the anterior sclera microstructure may be affected by myopia. If effective, this portable, inexpensive and user‐friendly system could be an important part of routine eye examinations.