Incidence of disability and its associated factors in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study
Incidence of disability and its associated factors in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study
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DOI：
10.1007/s00774-014-0573-y
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发表时间：
2015-03-01
影响因子：
3.3
通讯作者：
Nakamura, Kozo
中科院分区：
文献类型：
--
作者：
Yoshimura, Noriko;Akune, Toru;Nakamura, Kozo
我们调查了日本老年人的残疾发生率及其危险因素，以建立一个基于证据的残疾预防策略。为此，我们使用了2008年启动的运动系统器官纵向队列（LOCOMO）研究的数据，整合了日本9个社区的队列信息：东京（2个地区）、和歌山（2个地区）、广岛、新泻、三重、秋田和群马县。我们调查了8，454人（2，705名男性和5，749名女性）的年度残疾发生率，年龄为千分之一日元65岁。估计残疾发生率为3.58/100人-年（p-y）（男性：3.17/100 p-y;女性：3.78/100 p-y）。为了确定与残疾相关的因素，使用考克斯比例风险模型，残疾的发生率作为客观变量，年龄（+1岁），性别（vs. women），body build（0：正常/超重范围，BMI 18.5-27.5 kg/m2; 1：消瘦，BMI < 18.5 kg/m2; 2：肥胖，BMI > 27.5 kg/m2），以及地区差异（0：农村地区，包括和歌山、新泻、三重、秋田和群马; 1：城市地区，包括东京和广岛）作为解释变量。年龄、体型、地区差异对残疾的发生有显著影响（年龄，+1岁：风险比1.13，95%置信区间1.12-1.15，p < 0.001;体型，与消瘦：1.24，1.01-1.53，p = 0.041;体型，与肥胖：1.36，1.08-1.71，p = 0.009;居住与生活在农村地区：1.59，1.37-1.85，p < 0.001）。我们的结论是，较高的年龄，消瘦和肥胖，生活在农村地区将是残疾发生的危险因素。
We investigated the incidence of disability and its risk factors in older Japanese adults to establish an evidence-based disability prevention strategy for this population. For this purpose, we used data from the Longitudinal Cohorts of Motor System Organ (LOCOMO) study, initiated in 2008 to integrate information from cohorts in nine communities across Japan: Tokyo (two regions), Wakayama (two regions), Hiroshima, Niigata, Mie, Akita, and Gunma prefectures. We examined the annual occurrence of disability from 8,454 individuals (2,705 men and 5,749 women) aged a parts per thousand yen65 years. The estimated incidence of disability was 3.58/100 person-years (p-y) (men: 3.17/100 p-y; women: 3.78/100 p-y). To determine factors associated with disability, Cox's proportional hazard model was used, with the occurrence of disability as an objective variable and age (+1 year), gender (vs. women), body build (0: normal/overweight range, BMI 18.5-27.5 kg/m(2); 1: emaciation, BMI < 18.5 kg/m(2); 2: obesity, BMI > 27.5 kg/m(2)), and regional differences (0: rural areas including Wakayama, Niigata, Mie, Akita, and Gunma vs. 1: urban areas including Tokyo and Hiroshima) as explanatory variables. Age, body build, and regional difference significantly influenced the occurrence of disability (age, +1 year: hazard ratio 1.13, 95 % confidence interval 1.12-1.15, p < 0.001; body build, vs. emaciation: 1.24, 1.01-1.53, p = 0.041; body build, vs. obesity: 1.36, 1.08-1.71, p = 0.009; residence, vs. living in rural areas: 1.59, 1.37-1.85, p < 0.001). We concluded that higher age, both emaciation and obesity, and living in rural areas would be risk factors for the occurrence of disability.