Quantitative measurement of cartilage volume is possible using two-dimensional magnetic resonance imaging data sets.
Quantitative measurement of cartilage volume is possible using two-dimensional magnetic resonance imaging data sets.
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使用二维磁共振成像数据集可以定量测量软骨体积。
DOI：
10.1016/j.joca.2018.04.005
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发表时间：
2018
影响因子：
7
通讯作者：
Duryea,J
中科院分区：
文献类型：
--
作者：
Schaefer,LF;Nikac,V;Lynch,JA;Duryea,J
目的三维磁共振成像（MRI）扫描通常用于定量测量膝关节骨关节炎的软骨。然而，大量的MRI数据来自2D扫描，通常被认为不适合定量软骨评估。我们的研究的目标是证明，mLACS，局部区域软骨分割（拉克）方法的修改版本，可用于测量软骨体积的2D MRI images.MethodsWe研究了301随机选择的受试者从OA生物标志物联盟FNIH研究，骨关节炎倡议（OAI）内的嵌套病例对照研究。该研究包括基于放射学和疼痛进展的四个亚组。我们比较了应用于2D TSE扫描的mLACS与应用于3D DESS数据的拉克。Pearson相关系数用于建立拉克和mLACS之间的一致性，标准化反应均值（SRM）用于反应性，类内相关系数（ICC）用于测量读数器精度。Logistic回归分析的情况下/对照分析被用来比较两种方法之间的临床validity.ResultsWe foundR 2 = 0.76拉克和mLACS之间的相关性。拉克的响应性为SRM = 0.49，而mLACS为0.39。拉克和mLACS的主要病例/对照分析的比值比（OR）分别为1.62和1.78。mLACS的内部和读者之间的再现性值为ICC = 0.90和0.86，分别为conclusionThis研究表明，一个可重复的，响应，和临床有效的定量测量软骨体积可以使用2D TSE扫描与适度的损失相比，3D扫描的响应。
Purpose3D Magnetic resonance imaging (MRI) scans are generally used for quantitative cartilage measurements in knee osteoarthritis. However, a great deal of MRI data is from 2D scans, often thought to be unsuitable for quantitative cartilage assessment. The goal of our study was to demonstrate that mLACS, a modified version of the Local Area Cartilage Segmentation (LACS) method, could be used to measure cartilage volume on 2D MRI images.MethodsWe studied 301 randomly selected subjects from the OA Biomarkers Consortium FNIH Study, a nested case-control study within the Osteoarthritis Initiative (OAI). The study comprised four subgroups based on radiographic and pain progression. We compared mLACS applied to 2D TSE scans to LACS on 3D DESS data. The Pearson's correlation coefficient was used to establish agreement between LACS and mLACS, standardized response means (SRMs) for responsiveness, and intra-class correlation coefficients (ICCs) to measure reader precision. Logistic regression in a case/control analysis was used to compare the clinical validity between the two methods.ResultsWe foundR2= 0.76 for the correlation between LACS and mLACs. For LACS, the responsiveness was SRM = 0.49 compared to 0.39 for mLACS. The odds ratios (OR) for the primary case/control analyses were 1.62 for LACS and 1.78 for mLACS. The intra and inter reader reproducibility values for mLACS were ICC = 0.90 and 0.86, respectively.ConclusionThis study has demonstrated that a reproducible, responsive, and clinically valid quantitative measurement of cartilage volume can be made using 2D TSE scans with a modest loss of responsiveness compared to 3D scans.