Cyclophosphamide hemorrhagic cystitis.
Cyclophosphamide hemorrhagic cystitis.
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环磷酰胺出血性膀胱炎。
DOI：
10.3109/00365597009137596
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发表时间：
1970
影响因子：
--
通讯作者：
P. Langeland
中科院分区：
文献类型：
--
作者：
C. F. Liedberg;A. Rausing;P. Langeland
除了白细胞减少、血小板减少、恶心、呕吐、腹泻和脱发外，出血性膀胱炎是环磷酰胺治疗的一个非常严重的并发症。1966-1969年间收治的11例晚期恶性疾病患者均观察到此并发症。血尿的严重程度不一，从轻微的镜检到大量的危及生命的，并出现或不伴有膀胱炎症状。早期的尿培养没有生长，但发生了继发感染。膀胱镜检查发现轻度至中度血尿患者弥漫性上皮下出血。2例有严重膀胱炎症状的患者膀胱内可见大的肿瘤样肿块，另2例可见粘膜肿胀、肿胀。膀胱的显微镜检查显示，上皮下有许多宽厚的薄壁血管。粘膜肿胀、增厚或纤维化。可见坏死、钙化和囊性上皮巢。尿液细胞学检查显示变异型上皮异型性。
In addition to leucopenia, thrombocytopenia, nausea, vomiting, diarrhea and alopecia, hemorrhagic cystitis is a very serious complication of cyclophosphamide therapy. This complication was observed in 11 cases treated for advanced malignant disease in 1966-1969. the hematuria varied in severity from slight microscopic to profuse and life-threatening, and occurred with or without symptoms of cystitis. Early urinary culture has given no growth, but secondary infection has occurred. Cystoscopy revealed disseminated subepithelial bleeding in patients with mild to moderate hematuria. Large tumorlike masses were seen in the bladder in two patients with severe symptoms of cystitis and in others an edematous, swollen mucosa. Microscopic examination of the bladders showed many wide, thin-walled vessels beneath the epithelium. the mucous membrane was edematous, thickened or fibrotic. Necrosis, calcification and cystic epithelial nests were found. Cytologic examination of the urine showed epithelial atypia of varyin...