EARLY-ONSET ALZHEIMERS-DISEASE - CLINICAL PREDICTORS OF INSTITUTIONALIZATION AND DEATH
EARLY-ONSET ALZHEIMERS-DISEASE - CLINICAL PREDICTORS OF INSTITUTIONALIZATION AND DEATH
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DOI：
10.1212/wnl.37.6.980
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发表时间：
1987-06-01
期刊：
影响因子：
9.9
通讯作者：
GWYTHER, LP
中科院分区：
文献类型：
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作者：
HEYMAN, A;WILKINSON, WE;GWYTHER, LP
对92例白色早发性阿尔茨海默病患者进行随访观察，以确定人口统计学、临床和神经心理学因素对机构化或死亡的预测。进入研究后5年的累积死亡率为23.9%，而预期死亡率为9.5%。5年累计入住养老院率为62.8%。研究发现，患者进入研究时的语言能力，他们在认知功能的简短筛选测试中的得分，以及他们对临床痴呆症的总体评分是随后机构护理和死亡的预测因素。患者的年龄对这些预测因素有显著的修正作用，与具有相同程度功能障碍的老年人相比，患有严重认知障碍的年轻患者的住院和死亡风险更大。
Follow-up observations were made of 92 white patients with early-onset Alzheimer''s disease to determine the demographic, clinical, and neuropsychological factors predictive of institutionalization or death. The cumulative mortality rate 5 years after entry into the study was 23.9%, compared with an expected rate of 9.5%. The 5-year cumulative rate of admission to nursing homes was 62.8%. The language ability of the patients on entry to the study, their scores on a brief screening test of cognitive function, and their overall ratings of clinical dementia were found to be predictors of subsequent institutional care and death. The age of the patients had a significant modifying effect on these predictive factors, resulting in a greater risk of institutionalization and death in younger patients with severe cognitive impairment as compared with older individuals with the same degree of dysfunction.