Metabolic Diseases Downregulate the Majority of Histone Modification Enzymes, Making a Few Upregulated Enzymes Novel Therapeutic Targets--"Sand Out and Gold Stays".
Metabolic Diseases Downregulate the Majority of Histone Modification Enzymes, Making a Few Upregulated Enzymes Novel Therapeutic Targets--"Sand Out and Gold Stays".
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DOI：
10.1007/s12265-015-9664-y
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发表时间：
2016-02
影响因子：
3.4
通讯作者：
Yang XF
中科院分区：
文献类型：
--
作者：
Shao Y;Chernaya V;Johnson C;Yang WY;Cueto R;Sha X;Zhang Y;Qin X;Sun J;Choi ET;Wang H;Yang XF
为了确定组蛋白修饰酶的表达是否在生理和病理条件下受到调节，我们采用了实验室开创的实验数据库挖掘方法，以确定19种人类和17种小鼠组织中164种酶的全景表达谱。我们的新的金字塔模型表明，心脏和T细胞是组蛋白乙酰化/去乙酰化、甲基化/去甲基化程度最高的组织之一;和3）组蛋白酶在代谢疾病和Treg极化/分化中下调比上调更多，但在肿瘤中不是。这些结果已经证明了一种新的工作模型“砂出和黄金停留”，其中代谢疾病中组蛋白酶的下调多于上调使得一些上调的酶成为代谢疾病和Treg活性中的潜在新治疗靶标。
To determine whether the expression of histone modification enzymes is regulated in physiological and pathological conditions, we took an experimental database mining approach pioneered in our labs to determine a panoramic expression profile of 164 enzymes in 19 human and 17 murine tissues. We have made the following significant findings: 1) Histone enzymes are differentially expressed in cardiovascular, immune and other tissues; 2) Our new pyramid model showed that heart and T cells are among a few tissues in which histone acetylation/deacetylation, histone methylation/demethylation are in the highest varieties; and 3) Histone enzymes are more downregulated than upregulated in metabolic diseases and Treg polarization/differentiation, but not in tumors. These results have demonstrated a new working model of “sand out and gold stays,” where more downregulation than upregulation of histone enzymes in metabolic diseases makes a few upregulated enzymes the potential novel therapeutic targets in metabolic diseases and Treg activity.