The appearance of Thy-1- donor T cells in the peripheral circulation 3-6 weeks after bone marrow transplantation suggests an extrathymic origin.
The appearance of Thy-1- donor T cells in the peripheral circulation 3-6 weeks after bone marrow transplantation suggests an extrathymic origin.
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骨髓移植后3-6周，外周循环中出现Thy-1-供体T细胞表明胸腺外起源。
DOI：
10.1093/intimm/8.2.171
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发表时间：
1996
影响因子：
4.4
通讯作者：
Harrison,DE
中科院分区：
文献类型：
--
作者：
Zhong,RK;Donnenberg,AD;Edison,L;Harrison,DE
Donor and host T cells were distinguished by T cell antigen marker Thy-1 isotype and cytoplasmic isozyme Gpi-1 in thisstudy of bone marrow transplantation between congenic mice. During the first 3–6 weeks after irradiation and marrowtransfer, percentages of cells bearing the donor Thy-1 isotype in the periphery are much lower than percentages of T cells bearing the donor Gpi-1 marker. Apparently a population of Thy-1−donor T cells exists for several weeks after bone marrow transplantation. Further study showed that this population of CD3+, Thy-1−donor T cells expressed CD4+or CD8+and was found in peripheral blood and spleen but not in the thymus. This finding suggests their extrathymic origin.
