In vivo proliferation of naive and memory influenza-specific CD8+ T cells
In vivo proliferation of naive and memory influenza-specific CD8+ T cells
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DOI：
10.1073/pnas.96.15.8597
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发表时间：
1999-07-20
影响因子：
11.1
通讯作者：
Doherty, PC
中科院分区：
文献类型：
--
作者：
Flynn, KJ;Riberdy, JM;Doherty, PC
病毒特异性CD8(+) T细胞反应已经通过原发性和继发性流感肺炎的发展、效应和恢复阶段进行了分析，显然，大多数（如果不是全部）表达克隆型受体的记忆T细胞结合流感核蛋白（NP）（366-374）肽+H-2D(b) （NPP）的四聚体复合体在这种局部呼吸道感染过程中被诱导分裂。回忆反应的复制阶段大约在病毒不能再从肺中恢复的时候结束，而一些原发CD8(+)NPP(+) T细胞可能会再增殖几天。在继发性攻击小鼠的淋巴组织中，CD8(+)NPP（+）记忆T细胞的数量大大增加，在随后的100天内，平均患病率逐渐下降，尽管至少有一些淋巴细胞继续循环。因此，细胞介导免疫的特点是抗原特异性CD8（+）的大量增殖，而在同源肽缺失的情况下，淋巴细胞的周转程度是可变的，处于低水平，并可能受到交叉感染的影响。
The virus specific CD8(+) T cell response has been analyzed through the development, effector, and recovery phases of primary and secondary influenza pneumonia, Apparently, most, if not all, memory T cells expressing clonotypic receptors that bind a tetrameric complex of influenza nucleoprotein (NP)(366-374) peptide+H-2D(b) (NPP) are induced to divide during the course of this localized respiratory infection. The replicative phase of the recall response ends about the time that virus can no longer be recovered from the lung, whereas some primary CD8(+)NPP(+) T cells may proliferate for a few more days, The greatly expanded population of CD8(+)NPP(+) memory T cells in the lymphoid tissue of secondarily challenged mice declines progressively in mean prevalence over the ensuing 100 days, despite the fact that at least some of these lymphocytes continue to cycle, The recall of cell-mediated immunity thus is characterized by massive proliferation of the antigen-specific CD8(+) set, whereas the extent of lymphocyte turnover in the absence of cognate peptide is variable, at a low level, and can be influenced by intercurrent infection.