Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is different in children compared to in adults: a study of UK and Dutch clinical cohorts.
Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME) is different in children compared to in adults: a study of UK and Dutch clinical cohorts.
复制标题
DOI：
10.1136/bmjopen-2015-008830
复制
发表时间：
2015-10-28
期刊：
影响因子：
2.9
通讯作者：
Crawley E
中科院分区：
文献类型：
--
作者：
Collin SM;Nuevo R;van de Putte EM;Nijhof SL;Crawley E
探讨儿童、青少年和成人慢性疲劳综合征/肌痛性脑脊髓炎（CFS/ME）之间的差异。来自英国8个儿科和27个成人CFS/ME服务的临床队列与来自荷兰的儿科随机对照试验的比较。成果指标包括：疲劳（UK-Chalder疲劳量表）;残疾（UK-SF-36身体功能子量表; Netherlands-CHQ-CF 87）;上学、疼痛、焦虑和抑郁（UK-Hospital Anxiety & Depression Scale，Spence Children's Anxiety Scale; Netherlands-Spielberger State-Trait Anxiety Inventory for Children，Children's Depression Inventory）;症状;评估时间;和体重指数。我们使用多项回归比较年轻（年龄<12岁）和年长（年龄12-18岁）的儿童与成人，并使用逻辑回归比较英国和荷兰的青少年。 与青少年和成年人相比，年幼儿童的性别平衡更加平等。成年人有更多的残疾和疲劳，并且生病的时间更长。年龄较小的儿童不太可能有认知症状（OR 0.18（95% CI 0.13至0.25）），更可能出现喉咙痛（OR 1.42（1.07至1.90））。与成年人相比，青少年更容易头痛（81.1%，OR 1.56（1.36%至1.80%）），淋巴结触痛、心悸、头晕、全身不适和疼痛的可能性较小。与成年人相比，青少年更可能患有共病抑郁症（OR 1.51（1.33至1.72）），而不太可能患有焦虑症（OR 0.46（0.41至0.53））。儿科医生需要认识到CFS/ME儿童的表现与成人不同。这些差异是否反映了潜在的病因病理学需要进一步研究。FITNET试验注册号为ISRCTN 59878666和NCT 00893438。本文包括本试验数据的次要（结果后）分析，但与试验结局无关。
To investigate differences between young children, adolescents and adults with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Comparison of clinical cohorts from 8 paediatric and 27 adult CFS/ME services in the UK and a paediatric randomised controlled trial from the Netherlands. Outcome measures include: fatigue (the UK—Chalder Fatigue Scale); Disability (the UK—SF-36 physical function subscale; the Netherlands—CHQ-CF87); school attendance, pain, anxiety and depression (the UK—Hospital Anxiety & Depression Scale, Spence Children's Anxiety Scale; the Netherlands—Spielberger State-Trait Anxiety Inventory for Children, Children's Depression Inventory); symptoms; time-to-assessment; and body mass index. We used multinomial regression to compare younger (aged <12 years) and older (aged 12–18 years) children with adults, and logistic regression to compare UK and Dutch adolescents. Younger children had a more equal gender balance compared to adolescents and adults. Adults had more disability and fatigue, and had been ill for longer. Younger children were less likely to have cognitive symptoms (OR 0.18 (95% CI 0.13 to 0.25)) and more likely to present with a sore throat (OR 1.42 (1.07 to 1.90). Adolescents were more likely to have headaches (81.1%, OR 1.56 (1.36% to 1.80%)) and less likely to have tender lymph nodes, palpitations, dizziness, general malaise and pain, compared to adults. Adolescents were more likely to have comorbid depression (OR 1.51 (1.33 to 1.72)) and less likely to have anxiety (OR 0.46 (0.41 to 0.53)) compared to adults. Paediatricians need to recognise that children with CFS/ME present differently from adults. Whether these differences reflect an underlying aetiopathology requires further investigation. FITNET trial registration numbers are ISRCTN59878666 and NCT00893438. This paper includes secondary (post-results) analysis of data from this trial, but are unrelated to trial outcomes.