The Parkinson's Disease Questionnaire (PDQ-39): development and validation of a Parkinson's disease summary index score
The Parkinson's Disease Questionnaire (PDQ-39): development and validation of a Parkinson's disease summary index score
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DOI：
10.1093/ageing/26.5.353
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发表时间：
1997-09-01
期刊：
影响因子：
6.7
通讯作者：
Hyman, N
中科院分区：
文献类型：
--
作者：
Jenkinson, C;Fitzpatrick, R;Hyman, N
目的：简要概述帕金森病问卷(PDQ-39)的编制和效度，并为该量表作为健康状况评分或单指数数据的使用提供证据。设计：PDQ-39分两次调查。对在英国帕金森氏病协会当地分支机构登记的患者进行的邮寄调查(n=405)，以及对前往神经科诊所治疗帕金森病的患者进行的调查(n=146)。对PDQ-39的八个维度的数据进行因子分析。结果：在邮寄调查中，227名患者收回了问卷(58.2%)，再加上临床评估(哥伦比亚评定量表和Hoehn和Yahr分期评分)。在临床样本中接触的所有146名患者都同意参加。对PDQ-39的8个维度进行了高阶主成分因子分析，得到了两个数据集上的一个因子。因此，决定将这八个领域的分数相加，得出一个单一的指数数字。通过信度检验和结构效度检验，对该指标的心理测量学特性进行了研究。讨论：来自PDQ-39的数据既可以用轮廓形式表示，也可以用单指数图形表示。在旨在确定治疗方案对帕金森氏病患者的功能和幸福感的特定方面的影响的研究中，该概况应该是有价值的，而PDSI将提供疾病对功能和幸福感的影响的总分，并将用于评估不同治疗的总体效果。此外，PDSI减少了统计比较的次数，因此在从PDQ-39探索数据时减少了机率的作用。
Objectives: to briefly outline the development and validation of the Parkinson's Disease Questionnaire (PDQ-39) and then to provide evidence for the use of the measure as either a profile of health status scores or a single index figure.Design: the PDQ-39 was administered in two surveys. a postal survey of patients registered with local branches of the Parkinson's Disease Society of Great Britain (n = 405) and a survey of patients attending neurology clinics for treatment for Parkinson's disease (n = 146). Data from the eight dimensions of the PDQ-39 were factor-analysed. This produced a single factor on the data from both surveys.Outcome measures: the eight dimensions of the PDQ-39 and the new single index score-the Parkinson's disease summary index (PDSI), together with clinical assessments (the Columbia rating scale and the Hoehn and Yahr staging score).Results: in the postal survey 227 patients returned questionnaires (58.2%). All 146 patients approached in the clinic sample agreed to take part. Higher-order principal-components factor analysis was undertaken on the eight dimensions of the PDQ-39 and produced one factor on both datasets. Consequently it was decided that the scores of the eight domains could be summed to produce a single index figure. The psychometric properties of this index were explored using reliability tests and tests of construct validity. The newly derived single index was found to be both internally reliable and valid.Discussion: data from the PDQ-39 can be presented either in profile form or as a single index figure. The profile should be of value in studies aimed at determining the impact of treatment regimes upon particular aspects of functioning and well-being in patients with Parkinson's disease, while the PDSI will provide a summary score of the impact of the illness on functioning and well-being and will be of use in the evaluation of the overall effect of different treatments. Furthermore, the PDSI reduces the number of statistical comparisons and hence the role of chance when exploring data from the PDQ-39.