Promoter motifs of olfactory receptor genes expressed in distinct topographic patterns
Promoter motifs of olfactory receptor genes expressed in distinct topographic patterns
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DOI：
10.1016/j.ygeno.2006.02.005
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发表时间：
2006-06-01
期刊：
影响因子：
4.4
通讯作者：
Strotmann, Joerg
中科院分区：
文献类型：
--
作者：
Hoppe, Reiner;Breer, Heinz;Strotmann, Joerg
鉴定了在鼻上皮中以簇状模式排列的嗅觉感觉神经元中表达的新型嗅觉受体编码基因，其是mOR 262（批准的基因符号Olfr）家族的典型基因。这些基因在其转录起始位点上游共享序列基序，这些序列基序与先前确定为mOR 262基因特征的序列基序高度相关，表明这些调控元件可能有助于控制其独特的表达模式。启动子分析的基因编码的I类受体，在背侧区域的上皮细胞中表达揭示了一个不同的，但又共同的一组序列基序。I类基因启动子的一个突出特征是多个O/E样结合位点，并且事实上鉴定了与I类OR基因的推定启动子区域结合的O/E型转录因子。研究结果支持的概念，这些OR基因的启动子区域的共同元素可能会决定其同源上皮表达模式。(c)2006年爱思唯尔公司All rights reserved.
Novel olfactory receptor-encoding genes that are expressed in olfactory sensory neurons arranged in a clustered pattern in the nasal epithelium, typical of the mOR262 (approved gene symbol Olfr) family, were identified. The genes share sequence motifs upstream of their transcription start sites that are highly related to those previously identified as characteristic of the mOR262 genes, suggesting that these regulatory elements may contribute to governing their unique expression pattern. Promoter analyses of genes encoding class I receptors that are expressed in the dorsal region of the epithelium revealed a different, but again common set of sequence motifs. A prominent feature of the class I gene promoters are multiple O/E-like binding sites, and O/E-type transcription factors that bind to the putative promoter region of class I OR genes were in fact identified. The findings support the concept that common elements in the promoter region of these OR genes may determine their congenic expression pattern in the epithelium. (c) 2006 Elsevier Inc. All rights reserved.