Effect of Hemodialysis on the Hypersulfatemia of Chronic Renal Failure
Effect of Hemodialysis on the Hypersulfatemia of Chronic Renal Failure
复制标题
血液透析对慢性肾衰竭高硫酸盐血症的影响
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
B. Kirschbaum
中科院分区：
文献类型：
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作者：
B. Kirschbaum
肾小球滤过率严重降低的患者血液中硫酸盐的浓度可增加八倍。硫酸盐几乎全部以氨基酸半胱氨酸和蛋氨酸的形式进入体内，并主要以无机硫酸盐的形式留在尿液中。肾功能衰竭时血浆中浓度可能超过 2.5 mol/L，并使阴离子间隙增加 5 mEq/L。在作者和同事的研究中，使用大型透析器和快速的血流速度进行血液透析可以有效地将血浆中硫酸盐的浓度在透析后立即降低至正常水平；硫酸盐的削减率实际上超过了尿素的削减率。两个比率之间观察到显着相关性。硫酸盐浓度与其他数据相结合，可能有助于估计饮食中蛋白质的摄入量和监测酸碱平衡的控制。 ASAIO杂志1998； 44：314-318。
Concentrations of sulfate can increase eightfold in the blood of patients with severe reductions in glomerular filtration rate. Sulfate enters the body almost exclusively as the amino acids cysteine and methionine, and leaves in the urine predominantly as inorganic sulfate. Concentrations in plasma may exceed 2.5 mol/L in renal failure, and raise the anion gap by 5 mEq/L. In studies by the author and colleagues, hemodialysis using large dialyzers and brisk blood flow rates effectively lowered the concentrations of sulfate in plasma to normal in the immediate post dialysis period; the sulfate reduction ratio actually exceeded the urea reduction ratio. Significant correlation was observed between the two ratios. Concentrations of sulfate, in conjunction with other data, may prove useful for estimating dietary intake of protein and monitoring control of acid-base balance. ASAIO Journal 1998; 44:314–318.