Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond.
Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond.
复制标题
在白血病及其他地区，FBXW7泛素连接酶的新兴角色。
DOI：
10.1016/j.ceb.2015.09.003
复制
发表时间：
2015-12
影响因子：
7.5
通讯作者：
Aifantis I
中科院分区：
文献类型：
--
作者：
Kourtis N;Strikoudis A;Aifantis I
蛋白质降解在细胞分裂、生长和分化的不同途径中起着关键作用。参与致癌途径的关键蛋白的异常稳定在癌症中经常被观察到。SCFFbxw7泛素连接酶在包括T细胞急性淋巴细胞性白血病在内的人类癌症中经常发生突变，说明了适当的蛋白质周转的重要性。最近的研究揭示了Fbxw7的新底物，并阐明了它在干细胞分化和干细胞样细胞扩张中的作用，从而推动了肿瘤的发生。详细了解Fbxw7调控的蛋白质网络在癌症发生和发展中的作用将有助于确定人类癌症的候选干预靶点。
Protein degradation plays key roles in diverse pathways in cell division, growth and differentiation. Aberrant stabilization of crucial proteins participating in oncogenic pathways is often observed in cancer. The importance of proper protein turnover is exemplified by the SCFFbxw7 ubiquitin ligase, which is frequently mutated in human cancer, including T cell acute lymphoblastic leukemia. Recent studies have revealed novel substrates of Fbxw7 and shed light on its role on differentiation of stem cells and expansion of stem-cell-like cells driving tumorigenesis. Detailed understanding of the contribution of the Fbxw7-regulated network of proteins in initiation and progression of cancer will facilitate the identification of candidate intervention targets in human cancer.