Simultaneous alignment and structure prediction of three RNA sequences.
Simultaneous alignment and structure prediction of three RNA sequences.
复制标题
DOI：
10.1504/ijbra.2005.007581
复制
发表时间：
2005-01-01
影响因子：
--
通讯作者：
Turcotte, Marcel
中科院分区：
文献类型：
--
作者：
Masoumi, Beeta;Turcotte, Marcel
比较RNA序列分析有助于非常准确的预测。最近对30 S和50 S核糖体亚基的测定提供了更多的支持证据。一些推理工具结合自由能最小化和比较分析，以提高二级结构预测的质量。本文研究了以下假设：与基于两个输入序列的预测相比，使用三个输入序列提高了平均准确度;当使用三个输入序列而不是两个输入序列时，任何序列的预测（最小准确度）都应该更准确;最后，三个序列的一致性结构可能不太代表单个序列。平均覆盖率应该更低。
Comparative RNA sequence analyses have contributed remarkably accurate predictions. The recent determination of the 30S and 50S ribosomal subunits bringing more supporting evidence. Several inference tools are combining free energy minimisation and comparative analysis to improve the quality of secondary structure predictions. This paper investigates the following hypotheses: the use of three input sequences improves the average accuracy compared to predictions based on two input sequences; the worse prediction (minimum accuracy) for any sequence should be more accurate when three input sequences are used rather than two; finally, the consensus structure of three sequences is probably less representative of the individual sequences. The average coverage should be less.