Polymer scaffolds with interconnected spherical pores and controlled architecture for tissue engineering:: Fabrication, mechanical properties, and finite element modeling
Polymer scaffolds with interconnected spherical pores and controlled architecture for tissue engineering:: Fabrication, mechanical properties, and finite element modeling
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DOI：
10.1002/jbm.b.30683
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发表时间：
2007-05-01
影响因子：
3.4
通讯作者：
Sanchez, Manuel Salmeron
中科院分区：
文献类型：
--
作者：
Diego, Raul Brigido;Estelles, Jorge Mas;Sanchez, Manuel Salmeron
提出了一种方法，可以定制组织工程中应用的 3D 支架的几何特性：孔隙率、孔径和互连喉部尺寸。通过扫描电子显微镜分析所制造的支架的结构。这些结构的机械性能在压缩应力-应变测量的基础上进行了讨论。此外，通过有限元建模（FEM）来估计支架的机械性能，其中在基于晶面心立方系统的理想结构上模拟压缩应力应变测试。基于有限元模型解释了结构的弹性特性，该模型支持实验结果的主要力学结论：第一线性区域中的压缩模量不取决于孔的几何特征（孔径、互连喉道尺寸），而仅取决于支架的总孔隙率。 (c) 2006 年 Wiley 期刊公司
A method is proposed in which the geometric properties of 3D scaffolds with application in tissue engineering can be tailored: porosity, pore size, and interconnection throat size. The architecture of the fabricated scaffolds is analyzed by scanning electron microscopy. The mechanical properties of these structures are discussed on the basis of compression stress-strain measurements. Moreover, the mechanical properties of the scaffolds are estimated by means of finite element modeling (FEM) in which the compression stress-strain test is simulated on an ideal structure based on the crystalline face centered cubic system. The elastic properties of the constructs are explained on the basis of the FEM model that supports the main mechanical conclusion of the experimental results: the compressive modulus in the first linear region does not depend on the geometric characteristics of the pore (pore size, interconnection throat size) but only on the total porosity of the scaffold. (c) 2006 Wiley Periodicals, Inc.