Multiple roles for Blimp-1 in B and T lymphocytes.
Multiple roles for Blimp-1 in B and T lymphocytes.
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DOI：
10.1007/0-387-46530-8_2
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发表时间：
2007
影响因子：
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通讯作者：
D. Savitsky;L. Cimmino;Tracy C. Kuo;G. Martins;K. Calame
中科院分区：
文献类型：
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作者：
D. Savitsky;L. Cimmino;Tracy C. Kuo;G. Martins;K. Calame
我们实验室对转录抑制因子 B 淋巴细胞诱导成熟蛋白 1 (Blimp-1) 进行了多年的研究。尽管Blimp-1最初被定性为终末分化浆细胞的调节剂，但越来越清楚的是，除了在胚胎发育过程中发挥关键作用外，Blimp-1还在成年小鼠的几种细胞谱系的分化功能中发挥着重要的调节作用。在这里，我们简要回顾了我们早期对 B 淋巴细胞谱系中的 Blimp-1 的研究，并描述了最近对 B 细胞的研究。我们还描述了我们的研究，这些研究证明了 Blimp-1 在 T 淋巴细胞谱系中的作用。
The transcriptional repressor B lymphocyte induced maturation protein-1 (Blimp-1) has been studied in our laboratory for several years. Although it was first characterized as a regulator of terminally differentiated plasma cells, it is becoming increasingly clear that Blimp-1 plays important regulatory roles in the differentiated function of several cell lineages in adult mice, in addition to critical roles during embryonic development. Here we briefly review our earlier work on Blimp-1 in the B lymphocyte lineage and describe more recent studies on B cells. We also describe our studies that demonstrate a role for Blimp-1 in the T lymphocyte lineage.