LATE EFFECTS OF ADJUVANT CHEMOTHERAPY AND POSTOPERATIVE RADIOTHERAPY ON QUALITY-OF-LIFE AMONG BREAST-CANCER PATIENTS
LATE EFFECTS OF ADJUVANT CHEMOTHERAPY AND POSTOPERATIVE RADIOTHERAPY ON QUALITY-OF-LIFE AMONG BREAST-CANCER PATIENTS
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DOI：
10.1016/0277-5379(91)90295-o
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发表时间：
1991-01-01
影响因子：
8.4
通讯作者：
SJODEN, PO
中科院分区：
文献类型：
--
作者：
BERGLUND, G;BOLUND, C;SJODEN, PO
通过向448名绝经前和绝经后乳腺癌患者邮寄问卷，评估辅助治疗对自觉健康和生活质量的远期影响，这些患者在初次治疗后2-10年无复发。这些患者被随机分配到术后放疗或辅助化疗，作为初次手术的替代。两种治疗方法之间的差异通常很小。然而，放射治疗的病人有明显更大的问题，减少耐力，症状有关的手术疤痕和焦虑。化疗患者明显有更多的嗅觉厌恶问题。两组的家庭内外活动水平、焦虑和抑郁症状相似。化疗患者的生活质量总体得分高于放疗患者。
Late effects of adjuvant treatment on perceived health and quality of fife were assessed through a questionnaire mailed to 448 premenopausal and postmenopausal breast cancer patients, free from recurrence 2-10 years after primary therapy. The patients had been randomised to postoperative radiotherapy or adjuvant chemotherapy as adjuncts to primary surgery. The differences between the two treatments were generally small. However, the radiotherapy patients had significantly greater problems with decreased stamina, symptoms related to the operation scar and anxiety. The chemotherapy patients had significantly more problems with smell aversion. Activity level inside and outside the home, anxiousness and depressive symptoms were similar in both groups. The chemotherapy patients scored their overall quality of fife higher than the radiotherapy patients.