The impact of stress and nutrition on bacterial-host interactions at the intestinal epithelial surface
The impact of stress and nutrition on bacterial-host interactions at the intestinal epithelial surface
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DOI：
10.1097/00075197-200503000-00016
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发表时间：
2005-03-01
影响因子：
3.1
通讯作者：
Wu, LC
中科院分区：
文献类型：
--
作者：
Alverdy, J;Zaborina, O;Wu, LC
综述的目的大多数研究肠道屏障功能的文献集中在细菌植物群的改变、粘膜上皮的变化或粘膜防御的完整性。本文综述了细菌与宿主之间相互作用的新概念，复杂的关系，既有利于在健康的时候，以及发生在疾病的变化和反应，最近的研究结果最近的工作已经证明了细菌和屏障的完整性和细菌本身之间的关系，这创造了一个共生关系，有利于双方的主机和植物群。宿主反应改变这种平衡，诱导细菌的变化，可能是有害的both.Summary随着更好地了解细菌-宿主相互作用在健康和危重病引起的变化，新的治疗方法，改善环境，都可能导致更好的恢复率在重症监护病房的患者。
Purpose of review Most literature that examines gut barrier function focuses on alterations in bacterial flora, changes in mucosal epithelium, or the integrity of the mucosal defenses. This review examines new concepts on the interaction between bacteria and the host, the complex relationships that serve to benefit both in times of health, and the alterations and responses that occur during illness.Recent findings Recent work has demonstrated a more complex relationship between bacteria and barrier integrity and between bacteria themselves, which creates a symbiotic relationship beneficial to both host and flora. Host responses alter this balance, inducing changes in bacteria that may be deleterious to both.Summary With a better understanding of the bacteria-host interactions in health and the alterations induced by critical illness, new therapies that improve the environment of both may lead to better recovery rates in intensive care unit patients.