18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference.
18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference.
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18-甲氧基可卡因可阻止可卡因获取，但可增强可卡因位置偏好的恢复。
DOI：
10.1016/j.neulet.2009.04.019
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发表时间：
2009
影响因子：
2.5
通讯作者：
Glick,StanleyD
中科院分区：
文献类型：
--
作者：
McCallum,SarahE;Glick,StanleyD
iboga生物碱同源物，18-甲氧基coronaridine（18-MC），减少自我管理的多种药物滥用。在这里，在一个有偏见的程序，我们调查是否18-MC将有一个可卡因条件性位置偏爱（CPP）在雄性SD大鼠的收购，表达和恢复类似的效果。虽然18-MC衰减可卡因CPP的获得，但它对CPP表达没有影响，并增强了消退后可卡因CPP的恢复。我们的研究结果与使用iboclavin获得的结果一致，但加强了这样一个概念，即CPP的获得，表达和恢复可能涉及单独的机制。
The iboga alkaloid congener, 18-methoxycoronaridine (18-MC), decreases self-administration of multiple drugs of abuse. Here, in a biased procedure, we investigated whether 18-MC would have a similar effect on the acquisition, expression and reinstatement of a cocaine conditioned place preference (CPP) in male Sprague-Dawley rats. While 18-MC attenuated acquisition of a cocaine CPP, it had no effect on CPP expression, and enhanced the reinstatement of cocaine CPP following extinction. Our results are consistent with those obtained using ibogaine, but reinforce the notion that acquisition, expression and reinstatement of a CPP likely involve separate mechanisms.