INCREASED TUMOR NECROSIS FACTOR-ALPHA MESSENGER-RNA AFTER CELLULAR EXPOSURE TO IONIZING-RADIATION
INCREASED TUMOR NECROSIS FACTOR-ALPHA MESSENGER-RNA AFTER CELLULAR EXPOSURE TO IONIZING-RADIATION
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DOI：
10.1073/pnas.86.24.10104
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发表时间：
1989-12-01
影响因子：
11.1
通讯作者：
WEICHSELBAUM, RR
中科院分区：
文献类型：
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作者：
HALLAHAN, DE;SPRIGGS, DR;WEICHSELBAUM, RR
我们报道了肿瘤坏死因子α。（TNF-α）在某些人肉瘤细胞中，用X射线处理后mRNA增加。TNF-α的增加mRNA伴随着TNF-α产生的增加。蛋白TNF-.alpha.增强了TNF-α-产生和不产生肿瘤细胞。这些数据表明，除了X射线的直接细胞毒性作用之外，TNF-α的产生也可能是由于X射线的直接细胞毒性作用。可能通过自分泌和旁分泌机制增加辐射致死率。TNF-α的组合。并且治疗性放射可用于临床癌症治疗。
We report that tumor necrosis factor .alpha. (TNF-.alpha.) mRNA is increased after treatment with x-rays in certain human sarcoma cells. An increase in TNF-.alpha. mRNA is accompanied by the increased production of TNF-.alpha. protein. TNF-.alpha. enhances radiation lethality in both TNF-.alpha.-producing and nonproducing tumor cells. These data suggest that, in addition to the direct cytotoxic effects of x-rays, production of TNF-.alpha. may add to radiation lethality through autocrine and paracrine mechanisms. Combinations of TNF-.alpha. and therapeutic radiation may be useful in clinical cancer therapy.