Evolution of Antibiotic Resistance without Antibiotic Exposure.
Evolution of Antibiotic Resistance without Antibiotic Exposure.
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DOI：
10.1128/aac.01495-17
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发表时间：
2017-11
影响因子：
4.9
通讯作者：
Andersson DI
中科院分区：
文献类型：
--
作者：
Knöppel A;Näsvall J;Andersson DI
抗生素的使用是抗生素耐药性出现的主要驱动因素。另一种未被探索的可能性是，抗性的进化是对其他选择压力的巧合反应。我们表明，在没有抗生素的情况下，选择可以减少对几种抗生素的敏感性。因此，细菌对自然环境的遗传适应可能通过产生抗性突变库来驱动抗性进化，当抗生素暴露发生时，选择可以作用于丰富抗性突变体。
Antibiotic use is the main driver in the emergence of antibiotic resistance. Another unexplored possibility is that resistance evolves coincidentally in response to other selective pressures. We show that selection in the absence of antibiotics can coselect for decreased susceptibility to several antibiotics. Thus, genetic adaptation of bacteria to natural environments may drive resistance evolution by generating a pool of resistance mutations that selection could act on to enrich resistant mutants when antibiotic exposure occurs.