Stem cell therapy for chronic lung diseases: Hope and reality
Stem cell therapy for chronic lung diseases: Hope and reality
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DOI：
10.1016/j.rmed.2010.03.022
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发表时间：
2010-07-01
影响因子：
4.3
通讯作者：
Agostini, Carlo
中科院分区：
文献类型：
--
作者：
Agostini, Carlo
许多最近发表的结果表明，使用干细胞再生肺组织的可能性。几个小组已经开发了使用造血干细胞，间质和内皮祖细胞以及胚胎细胞的各种动物模型，在这些动物中可以改善患病的肺。尽管有这些刺激的体内结果，在人类肺部疾病中可以使用干细胞衍生物之前，许多问题仍在等待中。这项简短的综述将研究令人鼓舞的数据，这些数据表明在肺部疾病治疗中使用干细胞的可能性。同时，回顾了有争议的发现，表明在提出在人类肺部疾病中利用干细胞之前，应谨慎行事。 （c）2010 Elsevier Ltd.保留所有权利。
A number of recently published results have suggested the possibility of using stem cells to regenerate lung tissue. Several groups have developed various animal models employing haematopoietic stem cells, mesenchymal and endothelial progenitors, and embryonic cells, in which it has been possible to ameliorate the diseased lung. Despite these stimulating in vivo results a number of questions are pending before stem cell derivatives can be used in human lung disorders. This brief review will examine encouraging data that suggest the possibility of using stem cells in the therapy of lung diseases. In parallel, controversial findings are reviewed indicating that caution should be recommended before proposing to utilize stem cells in human lung diseases. (C) 2010 Elsevier Ltd. All rights reserved.