NMDA-induced intrinsic voltage oscillations depend on L-type calcium channels in spinal motoneurons of adult turtles
NMDA-induced intrinsic voltage oscillations depend on L-type calcium channels in spinal motoneurons of adult turtles
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DOI：
10.1152/jn.1998.80.6.3380
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发表时间：
1998-12-01
影响因子：
2.5
通讯作者：
Hounsgaard, J
中科院分区：
文献类型：
--
作者：
Guertin, PA;Hounsgaard, J
在成年海龟的切片制备中，浴后应用 N-甲基-D-天冬氨酸 (NMDA) 诱导脊髓运动神经元的节律性活动。在河豚毒素（TTX）存在的情况下揭示了膜电位潜在的内在振荡。无论存在或不存在 TTX，NMDA 诱导的节律性均被 NMDA 受体拮抗剂和三种不同类别的 L 型钙通道拮抗剂消除或降低。这表明 NMDA 受体通道和 L 型钙通道都有助于 NMDA 诱导成熟脊髓运动神经元的内在振荡。
In a slice preparation from adult turtles, bath-applied N-methyl-D-aspartate (NMDA) induced rhythmic activity in spinal motoneurons. The underlying intrinsic oscillation in membrane potential was revealed in the presence of tetrodotoxin (TTX). NMDA-induced rhythmicity, in the presence or absence of TTX, was abolished or reduced by NMDA receptor antagonists and by three different classes of antagonists for L-type calcium channels. It is suggested that both NMDA receptor channels and L-type calcium channels contribute to NMDA-induced intrinsic oscillations in mature spinal motoneurons.