The role of protein-solvent interactions in protein unfolding
The role of protein-solvent interactions in protein unfolding
复制标题
DOI：
10.1016/s0958-1669(96)80119-4
复制
发表时间：
1996-08-01
影响因子：
7.7
通讯作者：
Dotsch, V
中科院分区：
文献类型：
--
作者：
Schiffer, CA;Dotsch, V
当蛋白质与自身的相互作用和蛋白质与其环境的相互作用之间的力平衡被破坏时，蛋白质解折叠发生。这种力平衡的破坏可能就像蛋白质周围正常水结构的扰动一样简单。正常的水-水相互作用的减少将导致水与蛋白质的相对相互作用的增加。水和蛋白质之间的相互作用数量的增加可以启动蛋白质的解折叠。这种蛋白质展开模型得到了一系列最近的实验和计算数据的支持。
Protein unfolding occurs when the balance of forces between the protein's interaction with itself and the protein's interaction with its environment is disrupted. The disruption of this balance of forces may be as simple as a perturbance of the normal water structure around the protein. A decrease in the normal water-water interaction will result in an increase in the relative interaction of water with the protein. An increase in the number of interactions between water and the protein may initiate a protein's unfolding. This model for protein unfolding is supported by a range of recent experimental and computational data.