ULTRASTRUCTURAL DEVELOPMENT OF ADIPOSE-TISSUE IN FETAL SHEEP
ULTRASTRUCTURAL DEVELOPMENT OF ADIPOSE-TISSUE IN FETAL SHEEP
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DOI：
10.1071/bi9780505
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发表时间：
1978-01-01
期刊：
影响因子：
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通讯作者：
ALEXANDER, G
中科院分区：
文献类型：
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作者：
GEMMELL, RT;ALEXANDER, G
s.c.的发展。用电镜观察了40-150日龄胎羊肾周脂肪组织。两个部位的脂肪组织均由外观相似的前脂肪细胞发育而来，线粒体很少，并在妊娠第70天左右开始积累脂质。在肾周脂肪中，在第80-90天之间存在线粒体的显著增殖，并且组织发育成棕色脂肪，细胞轮廓的特征在于具有许多明显嵴的许多线粒体，而在s.c.细胞发育成白色脂肪组织，观察到很少的线粒体和较少的嵴。两种组织中均可见多房和单房细胞。在130日龄胎仔中，首次在棕色脂肪细胞之间观察到神经，在较大胎仔中经常观察到神经，但在白色脂肪组织中观察到的神经很少。在垂体切除的胎儿中，无论是足月还是足月，s.c.脂肪和内部脂肪分别为白色和棕色脂肪组织，与正常胎儿相同，但在1164天龄胎儿中，肾周组织似乎是棕色和白色脂肪的混合物。
The development of s.c. and perirenal adipose tissue in fetal sheep of 40-150 days conceptual age was examined using EM. Adipose tissue from both sites developed from pre-adipose cells of similar appearance with few mitochondria and commenced accumulating lipid on about day 70 of gestation. In the perirenal fat there was marked proliferation of mitochondria between days 80-90 and the tissue developed into brown fat, cell profiles being characterized by many mitochondria with numerous distinct cristae, whereas in the s.c. cells which developed into white adipose tissue few mitochondria with fewer cristae were observed. Multilocular and unilocular cells occurred in both tissues near term. Nerves were 1st seen between brown adipose cells in a 130 day old fetus and were frequently seen in older fetuses, but very few nerves were seen in the white adipose tissue. In hypophysectomized fetuses, either full- or post-term, the s.c. fat and internal fat were white and brown adipose tissue respectively, as in normal fetuses, although in 1 164 day old fetus the perirenal tissue appeared to be a mixture of brown and white fat.